"The synthesis and characterization facilities of the SynBio3 platform's "Polymer" and "Peptide" platforms.

The "What's in it for me?" seminars organized by the Chemistry Research Center's various technology and service platforms are designed to enable you to discover or deepen your knowledge of the technical possibilities offered by the analysis and characterization equipment at your disposal.

Come and discover the synthesis and characterization facilities of the SynBio3 platform's "Polymer" and "Peptide" platforms.

After a general introduction to the SynBio3 platform, the Polymer platform will host a session on polymers and chromatography. The latest advances in liquid chromatography for polymer characterization will be discussed. The "Peptide" platform will present its activities around the synthesis of peptides and other classes of biomolecules, purification techniques and the characterization and quantification of the compounds prepared.

Speakers

• Prof. Gilles SUBRA (IBMM-SynBio3 and "Amino acids, heterocycles, peptides and proteins" team)

Technical section

• Dr. Vincent DARCOS (IBMM-SynBio3 and "Polymers for Health and Biomaterials" team) Title: Polymers and chromatography on SynBio3
• Dr. Pascal VERDIE (IBMM-SynBio3 and "Amino acids, heterocycles, peptides and proteins" team) Title: Peptides, separative and analytical techniques

Examples of scientific projects

• Dr. Minh-Thuong Khong (Post-doctoral fellow, IBMM-SynBio3 and "Polymers for Health and Biomaterials" team) Title: 13C-labeling of copolymers based on poly(lactic acid) and high sensitivity tracking of their degradation products traces by MALDI-TOF Mass Spectrometry.
• Dr. Elodie LOGEROT (Post-Doctoral Fellow, IGF) Title: Study of the mechanisms of pore formation by two-compound leukotoxins from Staphylococcus aureus.
• Jules SIMONIN-GARCIA (PhD student, IBMM) Title: SynBio3-plateau Peptides et enzymologie : étude de cas d'un screening de peptides clivables par une protéase 

About the speakers

Gilles Subra directs his research at IBMM in the field of peptide science. His main research topics lie at the interface of chemistry and biology, and include solid-phase and combinatorial chemistry methodologies, and the design of chemical tools to improve detection and quantification by mass spectrometry in biological media. He is also interested in the design of peptide-based materials and polymers. Key applications include the design of multi-ligand nanoparticles for cancer targeting, and the functionalization of medical devices and silicone dressings. His most recent research focuses on the design of peptide-based biomimetic hydrogels for 3D biomanufacturing and cellular therapies.

Vincent Darcos is a CNRS/HDR research engineer in IBMM's "Polymers for Health and Biomaterials" team. He is also scientific manager of the SynBio3 platform's "Polymer" platform. His research activities focus on macromolecular engineering to develop novel polymer biomaterials for healthcare applications. At SynBio3, he is currently developing new analytical tools, notably in chromatography, to characterize polymers with complex architectures.

Pascal Verdie is a UM research engineer in IBMM's Amino Acids, Heterocycles, Peptides and Proteins team. He is also operational manager of the SynBio3 platform. His research activities focus on peptide engineering for the development of selective ligands. At SynBio3, he is in charge of the automated peptide synthesis part and the platform's operational side (labeling, certification, etc.).

Minh-Thuong Khong is a post-doctoral fellow in the SynBio3 platform and the "Polymers for Health and Biomaterials" team. He works with Vincent Darcos and Benjamin Nottelet. His project, funded by the Occitanie region as part of the PRRI "Biopoltrace" project, aims to develop new methods for monitoring the in vivo degradation of polymers used in the medical and pharmaceutical fields.

Jules SIMONIN-GARCIA is a doctoral student in the second year of his thesis, supervised by Gilles SUBRA (IBMM) and Marie Morille (ICGM). His thesis focuses on the design of peptide-based biomaterials that are sensitive to their biological environment.

Elodie LOGEROT is a post-doctoral fellow supervised by Chérine Béchara and Sébastien Granier at the IGF. Her subject is the study of two-compound leukotoxins from Staphylococcus aureus that target G protein-coupled receptors to lyse host cells by forming octameric pores in the plasma membrane. Pore formation begins with the specific interaction between the toxins and the N-ter part of the receptors, and requires important conformational changes in the toxins. In order to unravel the underlying mechanisms, she is using several structural approaches to monitor the affinity between receptor N-ter peptides and bacterial toxins, and the effect of the interaction on the latter's conformation.

For the launch of this 4th seminar, a short, friendly format awaits you.

Meet us on June 06 at 9am, in the amphitheatre of the Balard research building.

Access to the campus with a QR code (code creation request to be sent by e-mail.
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