What is the purpose of the synthesis and characterization equipment in the "Polymer" and "Peptide" sections of the SynBio3 platform?

The "What is it for?" seminars offered by the various technology and service platforms of the Chemistry Research Cluster aim to help you discover or deepen your knowledge of the technical capabilities of the analysis and characterization equipment available to you.

Come and discover the synthesis and characterization equipment available on the "Polymer" and "Peptide" platforms of the SynBio3 platform.

After a general introduction to the SynBio3 platform, the "Polymer" panel will host a session on polymers and chromatography. The latest advances in liquid chromatography for polymer characterization will be discussed. The "Peptide" platform will present its activities in the synthesis of peptides and other classes of biomolecules, purification techniques, and the characterization and quantification of the compounds prepared.

Speakers

• Prof. Gilles SUBRA ( IBMM-SynBio3 and "Amino Acids, Heterocycles, Peptides, and Proteins" team)

Technical Section

• Dr. Vincent DARCOS (IBMM-SynBio3 and "Polymers for Health and Biomaterials" team) Title: Polymers and chromatography on SynBio3
• Dr. Pascal VERDIE (IBMM-SynBio3 and "Amino Acids, Heterocycles, Peptides, and Proteins" team) Title: Peptides, separation and analytical techniques

Examples of scientific projects

• Dr. Minh-Thuong Khong (Postdoctoral Fellow, IBMM-SynBio3 and "Polymers for Health and Biomaterials" team) Title: 13C-labeling of copolymers based on poly(lactic acid) and high sensitivity tracking of their degradation products traces by MALDI-TOF Mass Spectrometry.
• Dr. Elodie LOGEROT (Postdoctoral Fellow, IGF) Title: Study of the mechanisms of pore formation by two-component leukotoxins from Staphylococcus aureus.
• Jules SIMONIN-GARCIA (PhD student, IBMM) Title: SynBio3-plateau Peptides and enzymology: case study of a screening of peptides cleavable by a protease 

About the speakers

Gilles Subra conducts his research at the IBMM in the field of peptide science. His main research topics lie at the interface between chemistry and biology and focus in particular on solid-phase chemistry and combinatorial chemistry methodologies, and the design of chemical tools to improve detection and quantification by mass spectrometry in biological environments. He is also interested in the design of peptide-based materials and polymers. The main applications concern the design of multi-ligand nanoparticles for cancer targeting and the functionalization of medical devices and silicone dressings. His most recent research focuses on the design of peptide-based biomimetic hydrogels used for 3D biofabrication and cell therapies.

Vincent Darcos is a CNRS/HDR research engineer in the "Polymers for Health and Biomaterials" team at IBMM. He is also scientific director of the "Polymer" platform at SynBio3. His research focuses on macromolecular engineering to develop original polymer biomaterials for healthcare applications. At SynBio3, he is currently developing new analytical tools, particularly in chromatography, for characterizing polymers with complex architectures.

Pascal Verdie is a UM research engineer in the "Amino Acids, Heterocycles, Peptides, and Proteins" team at IBMM. He is also the operational manager of the SynBio3 platform. His research activities focus on peptide engineering for the development of selective ligands. At SynBio3, he is in charge of the peptide synthesis automation and the operational aspects of the platform (labeling, certification, etc.).

Minh-Thuong Khong is a postdoctoral researcher at the SynBio3 platform and the "Polymers for Health and Biomaterials" team. He works with Vincent Darcos and Benjamin Nottelet. His project, funded by the Occitanie region as part of the PRRI "Biopoltrace" project, aims to develop new methods for monitoring the in vivo degradation of polymers used in the medical and pharmaceutical fields.

Jules SIMONIN-GARCIA is a second-year doctoral student under the supervision of Gilles SUBRA (IBMM) and Marie Morille (ICGM). His thesis focuses on the design of peptide-based biomaterials that are sensitive to their biological environment.

Elodie LOGEROT is a postdoctoral researcher under the supervision of Chérine Béchara and Sébastien Granier at the IGF. Her research focuses on the study of two-component leukotoxins from Staphylococcus aureus that target G protein-coupled receptors to lyse host cells by forming octameric pores in the plasma membrane. Pore formation begins with the specific interaction between the toxins and the N-terminal part of the receptors, and requires significant conformational changes in the toxins. In order to unravel the underlying mechanisms, she uses several structural approaches to track the affinity between the N-terminal peptides of the receptors and the bacterial toxins, as well as the effect of the interaction on the conformation of the latter.

For the launch of this fourth seminar, a short and friendly format awaits you.

See you on June 6 at 9 a.m. in the lecture hall of the Balard research building.

Access to campus with a QR code (request for code creation to be sent by email.
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