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The IRCM develops cognitive, multidisciplinary and applied research in the field of oncology. This research involves researchers and clinicians, and aims to understand the different stages of tumorigenesis, and ultimately to identify new diagnostic and therapeutic strategies against cancer. The Institute's unifying theme is "Molecular Targets and Cancer Therapy: Discovery, Biology and Clinical Applications". The teams' projects are organized around 2 main themes: Therapeutic antibodies in oncology: innovation, engineering, biological response; Plasticity of solid tumors and their microenvironment: phenotypic plasticity and signaling pathways, genetic and epigenetic alterations, treatment resistance. Label: Unité Mixte de Research (UMR)Tutelles principales: UM, Inserm, ICMPôle de recherche: Biologie SantéDoctoral schools: Information, Structures, Systèmes; Sciences Chimiques et Biologiques pour la SantéPortail HAL : publications de la structure WEBSITE

The Montpellier Neuroscience Institute is dedicated to studying the pathophysiology and therapies for sensory (hearing, vision, somesthesia) and motor deficits. In their research, the teams draw on multi-disciplinary strategies such as molecular genetics, cellular imaging, electrophysiology and the study of integrated systems to develop preclinical trials. INM teams work on a wide range of research topics: Genetics and therapy of retinal blindness; Physiology and pathophysiology of the inner ear; Development and pathophysiology of proprioceptive systems; Physiology and therapeutic approaches to spinal cord pathologies. Label: Unité Mixte de Research (UMR)Tutelles principales: UM, InsermResearch cluster: Biology and HealthPhD school: Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

Label : UR_UM103Main supervisors : UM, CHU de NîmesResearch pole : Health BiologyPhD schools : Chemical and Biological Sciences for Health ; Information, Structures, SystemsHAL portal : publications of the structure

The IGMM conducts excellent, innovative basic research with potential spin-offs for biomedical, molecular and cellular medicine, in particular for the treatment of cancer and certain infectious or genetic diseases.The IGMM has a long-standing, internationally recognized reputation in the disciplinary fields that make up its main areas of research: RNA Biology; Gene Regulation and Epigenetics; Tumorigenesis/Cell Cycle and Death; Immunology/Virology/Biotherapies. In addition to these main lines of research, the IGMM also has an interdisciplinary cross-disciplinary axis involving mathematical/computational modelling and machine learning to better understand the pathophysiological phenomena at the heart of its scientific interests. Translational research plays an increasingly important role in IGMM research, with a growing number of hospital partnerships in and outside Montpellier, and the inclusion of hospital practitioners in its teams. Label: Unité Mixte de Research (UMR)Main supervisory bodies: CNRS, UMPôle de recherche: Biologie SantéDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

The IGH carries out outstanding fundamental research, and aims to bring this research to fruition in the field of pathology. The main research themes are genome and chromatin dynamics, developmental genetics, epigenetic control and molecular and cellular pathologies. The IGH has established three major lines of research: Genome dynamics and epigenetic control. The main aspects of this research concern DNA replication, maintenance of genome integrity, recombination and meiosis, retrotransposition and its control, chromatin and nuclear organization, regulation of gene expression, and RNA silencing. Developmental genetics. This research relies heavily on model organisms such as Drosophila and transgenic mice. Topics covered include the cell cycle and microtubule dynamics, gonadal development, RNA regulation in development, neurogenetics and memory. Understanding, diagnosing and treating human pathologies. Our work focuses on DNA metabolism, epigenetic regulation and signaling pathways in cancer, the molecular basis of myogenesis, immunity, inflammatory diseases, AIDS, neurodegenerative diseases and cellular therapies. Label: Unité Mixte de Research (UMR)Main supervisors: CNRS, UMPôle de recherche: Biologie SantéDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

The Institut de Génomique Fonctionnelle (IGF) is a multidisciplinary research center. The IGF's main activity is devoted to fundamental research using functional genomics to explore normal and pathological cell signaling and communication processes in various fields, particularly neurobiology, cardiology, endocrinology and oncology. Main activities range from structural pharmacology to systems biology, from the development of preclinical models of disease to translational research, to study a variety of pathologies, including neurological and psychiatric diseases, cardiac dysfunction, diabetes and cancer. One of IGF's main objectives is to identify new concepts in molecular medicine and evaluate new strategies for the development of diagnostic and therapeutic tools. Label: Unité Mixte de Research (UMR)Tutelles principales: CNRS, UM, InsermResearch cluster: Health BiologyPhD school: Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

The Institut Desbrest d'Épidémiologie et de Santé Publique (IDESP) aims to understand the development and evolution of chronic diseases, which affect over 30% of the population and absorb 80% of healthcare expenditure. To achieve this, the INSERM-University of Montpellier Joint Research Unit is using a new approach that takes account of the environment in the broadest sense, and of care trajectories through multimodal markers (clinical, biological, behavioral, psychological, social, environmental), drawing on the power of mathematics dedicated to massive data. The aim is to design optimized care and prevention pathways for relevant patient targets. Allergic and respiratory diseases, diabetes, obesity, kidney disease, vascular disease, inflammatory rheumatism and cancer are the focus of initial modeling. Label: Unité Mixte de Research (UMR)Tutelles principales: UM, InsermResearch cluster: Biology and HealthPhD schools: Information, Structures, Systems; Chemical and Biological Sciences for HealthHAL portal: publications of the structure SITE WEB - Page HAL

GENOPOLYS can be used for meetings, conferences and workshops in the fields of biology and health, thanks to its meeting rooms, amphitheatre and two practical rooms. GENOPOLYS is a hub of exchange, aimed at: the general public, with the aim of contributing to the citizen's scientific and medical culture, and participating in the dialogue between science and society; researchers and doctors, by promoting the integration of clinical research with fundamental research; industrialists, with the aim of integrating the world of research into business through training, interaction and development. Label: Unité d'Appui et de Research (UAR)Main supervisory bodies: CNRS, UM, InsermResearch cluster: Biology and Health WEBSITE

The "EuroMov Digital Health in Motion" research unit aims to foster the cross-fertilization of artificial intelligence, movement and health sciences to understand human behavioral plasticity in order to improve sensorimotor performance and envisage new therapeutic approaches, and to find in it a scientific metaphor, a source of inspiration for new digital approaches: automatic learning or adaptive control of complex systems, human/machine interaction and context-sensitive software systems. https://youtu.be/xaUOKgoUwYI?list=PL6WmOx60MnJe_iazdaxlxc1zC3Mx1K3Z0 This line of research on "Digital Health in Motion" ultimately aims to gain a better understanding of the etiology of human movement, considered as the level of integration of biological and cognitive phenomena, in the course of our ongoing informational exchanges with the environment. Perception In Action & Synchronization (PIAS): discover the laws governing human perception in moving agents (perception in action) and human-environment synchronization in general. Monitoring and Improving Behaviors (MIB): providing users with advice on how to improve their behaviors to achieve better health, quality of life or sports performance, with a particular focus on software engineering. Learning and Complexity Theme (LAC) focuses on the study of human learning and complexity through health movement signatures, clinical data and neural activity indicators, in particular by developing interpretable models. Semantics and Taxonomy of Movement (SemTaxM): to identify taxonomic classifications of movement and define a theory of semantics carried by movement and semantic models anchored in specific contexts. The transverse Factory axis aims to improve reproducibility of results and accelerate translational research and technology transfer by providing standardized and documented approaches with an open data dissemination strategy. Label: UR_UM102Main supervisors: UM, IMT Mines AlesResearch cluster: Biology and HealthPhD schools: Information, Structures, Systems; Human Movement SciencesHAL portal: publications of the structure WEBSITE

The DMEM laboratory is a joint research unit of INRA and the University of Montpellier. We are interested in understanding the tissue, cellular and molecular mechanisms that enable skeletal muscle to develop correctly and adapt to its environment. Our hypothesis is that abnormalities in muscle tissue adaptation to environmental changes (diet, level of physical activity) can modulate body homeostasis and, more broadly, health status. DMEM is therefore a fundamental research unit whose aim is to advance our knowledge of skeletal muscle function and physiology. We are also open to the possible applications of our research, as demonstrated by our partnerships with private companies interested in our results. Label: Unité Mixte de Research (UMR)Main supervisors: UM, INRAResearch cluster: Biology and HealthPhD schools: Human Movement Sciences; Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

Label : Unité Mixte de Research (UMR)Tutelles principales : UM, Inserm, UPS ToulouseResearch pole : Biology and HealthPhD school : Chemical and Biological Sciences for HealthHAL portal : publications of the structure WEBSITE

The Montpellier Cell Biology Research Center is a laboratory of the CNRS and the University of Montpellier. The CRBM is internationally recognized in the field of molecular and cell biology. Its research focuses on understanding the mechanisms controlling cell division, morphology and adhesion under normal and pathological conditions, with particular emphasis on cytoskeleton dynamics, post-translational modifications and intracellular signaling mechanisms regulating these cellular activities. Label: Unité Mixte de Research (UMR)Tutelles principales: CNRS, UMPôle de recherche: Biologie SantéDoctoral school: Sciences Chimiques et Biologiques pour la SantéPortail HAL : publications de la structure WEBSITE

https://youtu.be/U-4QGKRe4wY Le CEMIPAI est un laboratoire de services du CNRS et de l’université de Montpellier, ouvert aux équipes académiques et aux entreprises. Il s’organise autour de l’un des plus grands laboratoires de sécurité microbiologie de niveau L3 de France, permettant de travailler en atmosphère contrôlée sur les prélèvements biologiques infectieux et les agents biologiques de classe 3, comme le virus de l’immunodéficience humaine (VIH), les virus des hépatites ou les virus transmis par les moustiques (Chikungunya, Dengue, Zika), les bactéries pathogènes et les prions. Le CEMIPAI accueille les équipes, forme les chercheurs à la manipulation des agents infectieux et développe des tests en cultures cellulaires permettant de rechercher des molécules d’intérêt thérapeutique développées par les chercheurs du privé et du public. Des équipements de pointe en microscopie super résolue permet d’observer cellules infectées, virus et bactéries à des échelles nanométriques. Label : Unité d’Appui et de Recherche (UAR)Tutelles principales : CNRS, UMPôle de recherche : Biologie SantéPortail HAL : publications de la structure SITE WEB

The overall aim of the CBS is to carry out research at the cutting edge of structural biology, biophysics and bioengineering to identify and characterize the fundamental mechanisms of life and their regulation, at different scales of time and space (from single molecules to living tissues and organisms) and using integrative approaches. We are particularly interested in understanding the molecular and physical determinants of these processes, using state-of-the-art methodologies. We believe that the answer to these objectives involves the study of the structure and dynamics of supramolecular assemblies at different scales, as well as a detailed understanding of their assembly and regulation mechanisms. In addition, our ambition is to study these processes in more integrated contexts such as living cells or model organisms. Where possible, we also exploit this knowledge to design new therapeutic strategies for human health and disease. Label: Unité Mixte de Research (UMR)Main supervisory bodies: CNRS, UM, InsermResearch cluster: Biology and HealthPhD schools: Information, Structures, Systems; Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

BioCampus Montpellier is a federative research structure comprising 12 high-level technology platforms. These platforms serve a scientific community of 2,000 Professors , most of whose teams belong to the AGRO, CeMEB and EpiGenMed labexes. The UMS offers its services to players in the research units as well as to industrialists, with the aim of creating new collaborative networks. Its platforms offer "open access" services, scientific and technical expertise, training in the form of technology workshops, etc. Themes: Bioinformatics, Structural Biology, Breeding and Functional Exploration, Histology, Imaging, Small Animal Imaging, Molecular Combining, Recombinant Proteins, Genomics, Pharmacology, Proteomics, Vectorology. Label: Unité d'Appui et de Research (UAR)Tutelles principales: CNRS, UM, InsermResearch cluster: Health BiologyHAL portal: publications of the structure WEBSITE

Our project focuses on biocommunication between the cardiovascular/renal axis and metabolic tissues, in the complex pathophysiological context of metabolic syndrome. Our work aims to better characterize the pathophysiological mechanisms involved in the damage to different target tissues (cardiovascular and metabolic) during metabolic dysfunction, as well as the biocommunication pathways between these tissues. Thanks to this integrative approach to chronic diseases, we hope to develop new therapeutic strategies, with the aim of preventing damage to cardiovascular and metabolic tissues and thus reducing cardiovascular risk and metabolic dysfunction. Label : UR_UM101Main supervisor : UMPôle de recherche : Biologie SantéDoctoral school : Sciences Chimiques et Biologiques pour la SantéHAL portal : publications of the structure WEBSITE