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The Bacterial Virulence and Chronic Infections laboratory, VBIC (University of Montpellier, INSERM), was created on January 1, 2011, and is based at the UFR de Médecine Santé in Nîmes. Since January 2023, "L'équipe Projet Biologie des infections à Staphylocoques", located on the Triolet site in Montpellier, has joined VBIC. We have a "bench to bedside" approach, using basic and translational research to solve clinically relevant problems. Working closely with basic scientists, clinicians and biologists at the CHU de Nîmes, we use integrative, multidisciplinary approaches to understand the cellular and molecular basis of host/pathogen and microbial interactions in chronic wounds, and to apply our findings to clinical practice. We are also the National Reference Center for Brucellosis. We focus on the following pathologies: Brucellosis; Opportunistic infections caused by Burkholderia cepacia complex Chronic wound infections Staphylococcal infections. Label: Unité Mixte de Research (UMR)Tutelles principales: UM, InsermResearch cluster: Biology and HealthPhD school: Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

https://youtu.be/b6lRTV9H6AA?list=PL6WmOx60MnJe_iazdaxlxc1zC3Mx1K3Z0 Le laboratoire de Physiologie et Médecine Expérimentale du Cœur et des muscles, PhyMedExp, est une unité mixte de recherche (INSERM, CNRS, Université de Montpellier) créée le 1er janvier 2011. C’est une unité pluridisciplinaire fédérée autour de la physiologie et la physiopathologie des tissus contractiles (muscles cardiaque, lisse et strié), et leurs interactions avec leur environnement. Elle regroupe plus de 150 personnes sur 5 équipes et développe une stratégie de recherche allant de structures élémentaires (gènes et molécules), à l’organisme entier en passant par les cellules et les tissus. Les 5 équipes de la nouvelle unité PHYMEDEX sont : Équipe N°1 : Dynamique des couplages cardiaques. Équipe N°2 : Muscle et Déficiences d’Organes. Équipe N°3 : Maladies respiratoires et environnement. Équipe N°4 : Digestif : Développement et pathologies. Équipe N°5 : Maladies neuromusculaires et héréditaires. Label : Unité Mixte de Recherche (UMR)Tutelles principales : UM, Inserm, CNRSPôle de recherche : Biologie SantéÉcoles doctorales : Sciences du mouvement humain ; Sciences Chimiques et Biologiques pour la SantéPortail HAL : publications de la structure Site web

A multidisciplinary research unit made up of INSERM and EFS scientists, academics and university hospital staff. Competent in the field of infectiology research, UMR 1058 promotes translational research, between fundamental and clinical research, on the pathogenesis, transmission and control of HIV, other chronic infections (hepatitis viruses, mycobacteria) and emerging infections (arboviruses, prions), most often in partnership with research teams in the French West Indies and southern countries (sub-Saharan Africa and South-East Asia). UMR 1058 has received research funding from ANRS, ANR, the European Union (EDCTP and FP7), NIH/NIDA and various foundations. Label: Unité Mixte de Research (UMR)Tutelles principales: UM, Inserm, EFS, U ANTILLESResearch cluster: Biology and HealthPhD school: Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

The MMDN is an interdisciplinary laboratory dedicated to research into the biology of aging and neurodegenerative diseases. Using Drosophila, zebrafish, mouse and lemur animal models, and molecular biology, cell biology and pharmacology approaches, we target neurodegenerative diseases (Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis), rare diseases and spinal cord injury. Label : Unité Mixte de Research (UMR)Tutelles principales : UM, Inserm, EPHEPôle de recherche : Biologie SantéÉcole doctorale : Sciences Chimiques et Biologiques pour la SantéPortail HAL : publications de la structure SITE WEB

The research carried out by the LPHI teams aims to provide new insights into the study of biological membranes, in particular during parasitic (malaria, toxoplasmosis), bacterial (tuberculosis, salmonellosis, staphylococcal infections) and viral (antiviral defenses) infectious processes. The LPHI unit focuses on high-quality, innovative fundamental research in the field of biology. Research is based on integrated approaches involving genetics, molecular biology, biochemistry, structural biology and in vitro and in vivo cell biology. The laboratory collaborates with chemists and houses a team of theorists, physicists and mathematicians, to combine biology, chemistry, physics and mathematics in global or targeted multidisciplinary approaches to the biological processes studied. Label: Unité Mixte de Research (UMR)Main supervisory bodies: CNRS, INSERM, UMPôle de recherche: Biologie SantéDoctoral schools: Information, Structures, Systèmes; Sciences Chimiques et Biologiques pour la SantéHAL portal: publications of the structure WEBSITE

The aim of the Bioengineering and Nanoscience Laboratory's research is to contribute to the application of nanosciences to the fields of health and biology, with particular emphasis on dentistry. The main aim is to bring nanomaterials and nanosensors closer to clinical application, based on a high-quality methodological approach. Label : UR_UM104Main supervisor : UMPôle de recherche : Biologie SantéDoctoral school : Chemical and Biological Sciences for HealthHAL portal : publications of the structure WEBSITE

The IRMB brings together scientists and clinicians involved in regenerative medicine and immunotherapy, including both aspects of basic biology and innovative applications of regenerative therapy. The aim is to facilitate the transfer of stem cell biology research to clinical applications in coordination with clinicians specializing in chronic diseases (aging, rheumatoid arthritis, rare genetic diseases, diabetes, liver diseases, neurodegenerative diseases, musculoskeletal pathologies). Label: Unité Mixte de Research (UMR)Tutelles principales: UM, InsermResearch cluster: Biology and HealthPhD school: Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

Infectious diseases account for 35% of all deaths worldwide, and are the main cause of death in children and young adults. In addition, 17% of new cancer cases are thought to be caused by infectious agents. Infectiology research is therefore essential to better understand how an infectious agent multiplies within a living organism, so as to be able to prevent, treat and even cure the diseases induced by these infections. IRIM (Institut de Research en Infectiologie de Montpellier) is a research center focused on high-quality fundamental research in the fields of bacteriology, virology and immunity. Label: Unité Mixte de Research (UMR)Main supervisory bodies: CNRS, UMPolicy area: Biology and HealthPhD school: Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

The IRCM develops cognitive, multidisciplinary and applied research in the field of oncology. This research involves researchers and clinicians, and aims to understand the different stages of tumorigenesis, and ultimately to identify new diagnostic and therapeutic strategies against cancer. The Institute's unifying theme is "Molecular Targets and Cancer Therapy: Discovery, Biology and Clinical Applications". The teams' projects are organized around 2 main themes: Therapeutic antibodies in oncology: innovation, engineering, biological response; Plasticity of solid tumors and their microenvironment: phenotypic plasticity and signaling pathways, genetic and epigenetic alterations, treatment resistance. Label: Unité Mixte de Research (UMR)Tutelles principales: UM, Inserm, ICMPôle de recherche: Biologie SantéDoctoral schools: Information, Structures, Systèmes; Sciences Chimiques et Biologiques pour la SantéPortail HAL : publications de la structure WEBSITE

The Montpellier Neuroscience Institute is dedicated to studying the pathophysiology and therapies for sensory (hearing, vision, somesthesia) and motor deficits. In their research, the teams draw on multi-disciplinary strategies such as molecular genetics, cellular imaging, electrophysiology and the study of integrated systems to develop preclinical trials. INM teams work on a wide range of research topics: Genetics and therapy of retinal blindness; Physiology and pathophysiology of the inner ear; Development and pathophysiology of proprioceptive systems; Physiology and therapeutic approaches to spinal cord pathologies. Label: Unité Mixte de Research (UMR)Tutelles principales: UM, InsermResearch cluster: Biology and HealthPhD school: Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

Label : UR_UM103Main supervisors : UM, CHU de NîmesResearch pole : Health BiologyPhD schools : Chemical and Biological Sciences for Health ; Information, Structures, SystemsHAL portal : publications of the structure

The IGMM conducts excellent, innovative basic research with potential spin-offs for biomedical, molecular and cellular medicine, in particular for the treatment of cancer and certain infectious or genetic diseases.The IGMM has a long-standing, internationally recognized reputation in the disciplinary fields that make up its main areas of research: RNA Biology; Gene Regulation and Epigenetics; Tumorigenesis/Cell Cycle and Death; Immunology/Virology/Biotherapies. In addition to these main lines of research, the IGMM also has an interdisciplinary cross-disciplinary axis involving mathematical/computational modelling and machine learning to better understand the pathophysiological phenomena at the heart of its scientific interests. Translational research plays an increasingly important role in IGMM research, with a growing number of hospital partnerships in and outside Montpellier, and the inclusion of hospital practitioners in its teams. Label: Unité Mixte de Research (UMR)Main supervisory bodies: CNRS, UMPôle de recherche: Biologie SantéDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

The IGH carries out outstanding fundamental research, and aims to bring this research to fruition in the field of pathology. The main research themes are genome and chromatin dynamics, developmental genetics, epigenetic control and molecular and cellular pathologies. The IGH has established three major lines of research: Genome dynamics and epigenetic control. The main aspects of this research concern DNA replication, maintenance of genome integrity, recombination and meiosis, retrotransposition and its control, chromatin and nuclear organization, regulation of gene expression, and RNA silencing. Developmental genetics. This research relies heavily on model organisms such as Drosophila and transgenic mice. Topics covered include the cell cycle and microtubule dynamics, gonadal development, RNA regulation in development, neurogenetics and memory. Understanding, diagnosing and treating human pathologies. Our work focuses on DNA metabolism, epigenetic regulation and signaling pathways in cancer, the molecular basis of myogenesis, immunity, inflammatory diseases, AIDS, neurodegenerative diseases and cellular therapies. Label: Unité Mixte de Research (UMR)Main supervisors: CNRS, UMPôle de recherche: Biologie SantéDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

The Institut de Génomique Fonctionnelle (IGF) is a multidisciplinary research center. The IGF's main activity is devoted to fundamental research using functional genomics to explore normal and pathological cell signaling and communication processes in various fields, particularly neurobiology, cardiology, endocrinology and oncology. Main activities range from structural pharmacology to systems biology, from the development of preclinical models of disease to translational research, to study a variety of pathologies, including neurological and psychiatric diseases, cardiac dysfunction, diabetes and cancer. One of IGF's main objectives is to identify new concepts in molecular medicine and evaluate new strategies for the development of diagnostic and therapeutic tools. Label: Unité Mixte de Research (UMR)Tutelles principales: CNRS, UM, InsermResearch cluster: Health BiologyPhD school: Chemical and Biological Sciences for HealthHAL portal: publications of the structure WEBSITE

The Institut Desbrest d'Épidémiologie et de Santé Publique (IDESP) aims to understand the development and evolution of chronic diseases, which affect over 30% of the population and absorb 80% of healthcare expenditure. To achieve this, the INSERM-University of Montpellier Joint Research Unit is using a new approach that takes account of the environment in the broadest sense, and of care trajectories through multimodal markers (clinical, biological, behavioral, psychological, social, environmental), drawing on the power of mathematics dedicated to massive data. The aim is to design optimized care and prevention pathways for relevant patient targets. Allergic and respiratory diseases, diabetes, obesity, kidney disease, vascular disease, inflammatory rheumatism and cancer are the focus of initial modeling. Label: Unité Mixte de Research (UMR)Tutelles principales: UM, InsermResearch cluster: Biology and HealthPhD schools: Information, Structures, Systems; Chemical and Biological Sciences for HealthHAL portal: publications of the structure SITE WEB - Page HAL

GENOPOLYS can be used for meetings, conferences and workshops in the fields of biology and health, thanks to its meeting rooms, amphitheatre and two practical rooms. GENOPOLYS is a hub of exchange, aimed at: the general public, with the aim of contributing to the citizen's scientific and medical culture, and participating in the dialogue between science and society; researchers and doctors, by promoting the integration of clinical research with fundamental research; industrialists, with the aim of integrating the world of research into business through training, interaction and development. Label: Unité d'Appui et de Research (UAR)Main supervisory bodies: CNRS, UM, InsermResearch cluster: Biology and Health WEBSITE