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The University of Montpellier’s Research Ethics Committee was officially established on February 8, 2022. Its objective is to strengthen the mechanisms put in place by the University of Montpellier to promote awareness and adherence to ethical and professional principles in response to the questions raised by scientific advances and their contemporary societal implications, regardless of the field of research. The University of Montpellier Research Ethics Committee is authorized to provide advisory opinions on research projects and protocols across all scientific fields, particularly those involving human subjects, matters of privacy, and data relating to human subjects. However, projects falling under the scope of Law No. 2012-300 of March 5, 2012, concerning research involving human subjects (known as the “Jardé Law”) and its implementing decree No. 2016-1537 of November 16, 2016, and falling under Articles R.1121-1-1 and R.1121-1-2 of the Public Health Code defining research involving human subjects, are, for their part, subject to the jurisdiction of the Committees for the Protection of Human Subjects (CPP). Scope of Application and Operating RulesDownload GDPRDownload Calendar of Research Ethics CommitteesDownload Procedures for Submitting Requests to the Research Ethics Committee of theUM 1. Who may submit a case to the Research Ethics Committee (CER) of theUM ? Research project leaders who are employees of the University of Montpellier and the École Nationale Supérieure de Chimie, as well as any employee assigned to a research unit primarily supervised by the University of Montpellier or the École Nationale Supérieure de Chimie. For users at the University of Montpellier and the École Nationale Supérieure de Chimie, it is the scientific supervisor (internship advisor, thesis advisor, HDR scientific advisor, etc.) who may submit a request to the CER of theUM. 2. When should a request be submitted to the CER of theUM ? A request to the CER of theUM must be submitted prior to the start of a project. The referral must be submitted approximately three to four weeks before the meeting is held. 3. How do you submit a referral to the CER atUM ? The completed submission form must be sent by email. Would you like to learn more about submitting a referral to the CER? There are some important points to keep in mind when completing the form: Data use: Data storage (retention period, practical safeguards, identity of the person responsible) Data archiving procedures Clarification of the procedure for disseminating data to the public Data confidentiality: Process/method for anonymizing data Data confidentiality management Application(s) used for data collection Details about the project/study: Study start date Duration of the experiment Details on the study’s conduct Order of magnitude of potential earnings Protocol based on the experimental subjects Interview guide / Questionnaire Explanation of acronyms Consent: More explicit consent Written consent from legal guardians for minors under 15 years of age Provide the informed consent form Information sheet: Details of information provided to participants Adaptation of information sheets for different audiences Indication of potential risks of the study in the information sheet 4. What is the response time for theUM  Ethics Review Board (ERC)? Advisory ethical opinions are sent to project sponsors within three weeks of the meeting. Would you like to learn more about the responses provided by theUM  Ethics Review Board (ERC)? The CER may issue several types of opinions: Favorable opinion Favorable opinion subject to requested modifications* Unfavorable opinion Declaration of lack of jurisdiction *The opinion will specify the modifications, clarifications, or documents required for your research protocol. To prepare your amended application: You must highlight your responses to the requests made by the Research Ethics Committee (CER) of theUM in the submission form; Check the “amendment” box; Submit it via email. Depending on the CER’s instructions: “Approval by the file reviewers and the Chair of the Research Ethics Committee”: the application will be approved by the committee after receiving positive responses from the relevant parties. “Must be resubmitted to the Research Ethics Committee”: the application will be subject to a new review by the Research Ethics Committee.

BioCampus Montpellier (BCM) Biocommunication in Cardiometabolic Diseases (BC2M) BioCentre Lunaret Montpellier (BIOLuM) Stem Cells, Cellular Plasticity, Tissue Regeneration, and Immunotherapy for Inflammatory Diseases (IRMB) Center for the Study of Infectious Diseases and Anti-Infective Pharmacology (CEMIPAI) Center for Structural Biology (CBS) Montpellier Center for Cell Biology Research s (CRBM) Embryonic Development, Fertility, and Environment (DEFE) Muscle Dynamics and Metabolism (DMEM) EuroMov Digital Health in Motion (EuroMov DHM) Génopolys Initial Management and Prevention of Acute Organ Failures in Critically Ill Patients (IMAGINE) Institute of Human Genetics (IGH) Montpellier Institute of Molecular Genetics (IGMM) Institute of Functional Genomics (IGF) Montpellier Institute of Neurosciences (INM) Montpellier Institute for Research s in Oncology (IRCM) Montpellier Institute of Infectious Disease Research s (IRIM) Desbrest Institute of Epidemiology and Public Health (IDESP) Bioengineering and Nanosciences Laboratory (LBN) Laboratory of Pathogens and Host Immunity (LPHI) Molecular Mechanisms in Neurodegenerative Dementias (MMDN) Pathogenesis and Control of Chronic and Emerging Infections (PCCEI) Physiology and Experimental Medicine of the Heart and Muscles (PhyMedExp) Translational Research on HIV and Endemic and Emerging Infectious Diseases (TransVIHMI) Bacterial Virulence and Chronic Infections (VBIC) Partnership-Based Research Structures: Host-Vector-Parasite-Environment Interactions in Neglected Tropical Diseases Caused by Trypanosomatids (INTERTRYP) Modeling and Engineering of Complex Biological Systems for Diagnosis (Sys2Diag)

Doctoral Schools Affiliated with the Biology and Health Cluster (CBS2) — Chemical and Biological Sciences for Health The CBS2 doctoral school trains doctoral candidates in all fields of biology and health, from medicinal chemistry to clinical studies, and from genetics to behavior. Supported by the laboratories of the Biology-Health Cluster and the Doctoral College of the University of Montpellier, it offers training focused on and driven by research and prepares future PhDs for careers in both academia and the private sector. CBS2 Doctoral School Website SMH - Human Movement Sciences Doctoral School 463 “Human Movement Sciences” brings together the research capabilities of the major university clusters in the Greater Southeast (Aix-Marseille, Montpellier, and Nice) in the field of human movement and its neurological, physiological, mechanical, behavioral, cognitive, and societal determinants. ED SMH website Biology and Health Programs Website for the University of Montpellier’s academic programs

FHU T.I.E. “Triangular Analysis of Interactions Between Host, Infectious Agent, and Environment” Dr. A. MAKINSON (UM/Montpellier University Hospital) and Prof. E. TUAILLON (UM/Montpellier University Hospital) The University Hospital Federation (FHU) TIE [taɪ]—whose acronym refers to its overarching goal of modeling human–microorganism interactions, from emergence to long-term complications, through a triangulation between the host, infectious agents, and the environment—brings together stakeholders in the Montpellier-Nîmes region involved in research and care related to infectious diseases and related fields (microbiology, immunology, public health). Although the resources allocated to the FHUs are modest, these federations—which have existed in France since 2012—aim to stimulate translational research, improve the quality of care, and foster collaborations between university hospitals, research laboratories, and the private sector. FHU Regenhab 2.0 “Regenerative Medicine, Motion Modeling, and Rehabilitation” Prof. C. JORGENSEN (IRMB, U1183) and Dr. A. LACAMPAGNE (Phymedex, U1046)FHU Regenhab 2.0 website FHU Evocan-2 “Cancer Immunotherapies” Prof. G. CARTRON (UM/Montpellier University Hospital) and Dr. N. BONNEFOY (ICM, U1194) FHU Evocan website

IHU Immun4Cure The Immun4Cure project, led by the Montpellier University Hospital, Inserm, and the University of Montpellier, was awarded IHU status in May 2023 as part of the France 2030 plan.As an Initiative of Excellence, the IHU brings together expertise in the field of autoimmune diseases and is fully integrated into the MedVallée initiative, building on its strengths and reinforcing communities already recognized by the I-SITE designation. IHU Immun4Cure website CeAND The Center of Excellence on Autism and Neurodevelopmental Disorders (CeAND) is an interdisciplinary research network aimed at fostering interactions among researchers, practitioners in the field, as well as families and those directly affected, in order to promote and disseminate best practices in care and education. CeAND website CoEN The overall objective of the Center of Excellence in Neurodegenerative Diseases (CoEN) in Montpellier is to build a collaborative research program in the field of neurodegeneration that transcends national borders, focusing on critical mass and excellence. CoEN website

Investments for the Future The Investments for the Future program involves 35 billion euros, of which 22 billion euros are earmarked for higher education and research to strengthen France’s competitiveness on the global stage. Of these 22 billion euros, nearly 18 billion take the form of competitive calls for proposals. The University of Montpellier is heavily involved in this program through numerous projects in which it serves as the lead institution or a partner. Learn more ERC Grants The European Research Council coordinates and funds scientific projects “at the frontiers of knowledge” within the European Union through grants that recognize scientific excellence. This program is open to all disciplines. Current European Research Council projects: ERC Starting Grant Erika Burioli (Host-Pathogen-Environment Interactions Laboratory) with the HYPERCAN project, which focuses on transmissible cancers in mussels.Profile of Erika Burioli Paul Antonio (Géosciences Montpellier) with the UBEICH project, which proposes a new experimental method to refine the dating of the Earth’s inner core.Profile of Paul Antonio ERC Advanced Grant David Mouillot (MARBEC), whose BLUE-AFRICA project will conduct transdisciplinary research to assess the potential of coastal marine resources to reduce poverty and emigration in rural regions of East Africa affected by land aridification. Read the press release: ERC Synergy Grant recipient Daniele Di Pietro (Alexander Grothendieck Institute in Montpellier) with the NEMESIS project, which aims to understand how to overcome current technological barriers in numerical simulations of complex physical problems. Profile of Daniele Di Pietro Past ERC Grants Sara Cavaliere (Charles Gerhardt Institute of Montpellier) with the SPINAM project, which focuses on electrochemical devices for hydrogen energy conversion and storage. Video feature with Sara Cavaliere Key Initiatives To continue its strategy of supporting the scientific communities that define the site’s unique identity, the I-SITE Program of Excellence (PEI) designated five new key initiatives in April 2024. Three of them are internationally focused and funded by the UM2030 project under the France 2030 program – IDéES “Integration and Development of Idex and I-SITE”—while the other two, funded directly by the PEI, aim to bring together communities from various Montpellier-based research institutions around interdisciplinary themes to give them greater visibility. Key international initiatives underUM 2030: Foods: Nutrition and Food Systems Vect-OH: Infectious Risks and Vectors within a One Health Approach Water: Water Key PEI initiatives: KIPPT: Public Policies for Transition CLAPAS: Local Collaborative Research Initiatives on Plant and Agrosystem Health