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The Bacterial Virulence and Chronic Infections Laboratory (VBIC) (University of Montpellier, INSERM) was created on January 1, 2011, and is located at the Faculty of Medicine and Health Sciences in Nîmes. In January 2023, the Staphylococcal Infection Biology Project team, based at the Triolet site in Montpellier, joined VBIC. We take a bench-to-bedside approach, using fundamental and translational research to solve clinically relevant problems. Through close collaboration between basic scientists, clinicians, and biologists at the Nîmes University Hospital, we use integrative and multidisciplinary approaches to understand the cellular and molecular basis of host/pathogen interactions and microbial interactions in chronic wounds, and to apply our discoveries in clinical practice. We are also the National Reference Center for Brucellosis. We focus on the following pathologies: Brucellosis; Opportunistic infections caused by the Burkholderia cepacia complex Chronic wound infections Staphylococcal infections. Label: Joint Research Unit Research UMR) Main supervisory bodies: UM, Inserm Research cluster: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the organization WEBSITE

https://youtu.be/b6lRTV9H6AA?list=PL6WmOx60MnJe_iazdaxlxc1zC3Mx1K3Z0 Le laboratoire de Physiologie et Médecine Expérimentale du Cœur et des muscles, PhyMedExp, est une unité mixte de recherche (INSERM, CNRS, Université de Montpellier) créée le 1er janvier 2011. C’est une unité pluridisciplinaire fédérée autour de la physiologie et la physiopathologie des tissus contractiles (muscles cardiaque, lisse et strié), et leurs interactions avec leur environnement. Elle regroupe plus de 150 personnes sur 5 équipes et développe une stratégie de recherche allant de structures élémentaires (gènes et molécules), à l’organisme entier en passant par les cellules et les tissus. Les 5 équipes de la nouvelle unité PHYMEDEX sont : Équipe N°1 : Dynamique des couplages cardiaques. Équipe N°2 : Muscle et Déficiences d’Organes. Équipe N°3 : Maladies respiratoires et environnement. Équipe N°4 : Digestif : Développement et pathologies. Équipe N°5 : Maladies neuromusculaires et héréditaires. Label : Unité Mixte de Recherche (UMR)Tutelles principales : UM, Inserm, CNRSPôle de recherche : Biologie SantéÉcoles doctorales : Sciences du mouvement humain ; Sciences Chimiques et Biologiques pour la SantéPortail HAL : publications de la structure Site web

A multidisciplinary research unit composed of INSERM scientists, academics, and university hospital researchers. With expertise in the field of infectious disease research, UMR 1058 promotes translational research, combining fundamental and clinical work, on the pathogenesis, transmission, and control of HIV, other chronic infections (hepatitis viruses, mycobacteria) and emerging infections (arboviruses, prions), most often in partnership with research teams from the Caribbean and Southern countries (sub-Saharan Africa and Southeast Asia). UMR 1058 is supported and has obtained research funding from ANRS, ANR, the European Union (EDCTP and FP7), NIH/NIDA, and various foundations. Label: Joint Research Unit Research UMR) Main supervisory bodies: UM, Inserm, U ANTILLES Research cluster: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the organization WEBSITE

The MMDN is an interdisciplinary laboratory dedicated to research on the biology of aging and neurodegenerative diseases. We seek to understand the molecular mechanisms of normal and pathological aging and to propose new approaches for diagnosis and treatment.Using animal models such as Drosophila, zebrafish, mice, and lemurs, and through molecular biology, cell biology, and pharmacology approaches, we target neurodegenerative diseases (Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis), rare diseases, and spinal cord injury. Label: Joint Research Unit Research UMR) Main supervisory bodies: UM, Inserm, EPHE Research cluster: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the organization WEBSITE

The research conducted by the LPHI teams aims to provide new insights into the study of biological membranes, particularly during parasitic (malaria, toxoplasmosis), bacterial (tuberculosis, salmonellosis, staphylococcal infections) and viral (antiviral defenses) infectious processes. The LPHI unit focuses on high-quality, innovative fundamental research in the field of biology. Its research is based on the use of integrated approaches involving genetics, molecular biology, biochemistry, structural biology, and in vitro and in vivo cell biology. The laboratory collaborates with chemists and hosts a team of theorists, physicists, and mathematicians in order to combine biology, chemistry, physics, and mathematics in comprehensive or targeted multidisciplinary approaches to the biological processes studied. Label: Joint Research Unit Research UMR) Main supervisory bodies: CNRS, INSERM, UMP Research cluster: Biology and Health Doctoral schools: Information, Structures, Systems; Chemical and Biological Sciences for Health HAL portal: publications by the structure WEBSITE

The objective of the Bioengineering and Nanoscience Laboratory's research is to contribute to the application of nanoscience in the fields of health and biology, with a particular focus on dentistry. The main goal is to bring nanomaterials and nanosensors closer to clinical application by relying on a high-quality methodological approach. Label: UR_UM104Main supervisory body: UMPResearch center: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications by the organization WEBSITE

The IRMB brings together scientists and clinicians involved in regenerative medicine and immunotherapies, covering both fundamental biology and innovative applications of regenerative therapy. The aim is to facilitate the transfer of stem cell biology research to clinical applications in coordination with clinicians specializing in chronic diseases (aging, rheumatoid arthritis, rare genetic diseases, diabetes, liver diseases, neurodegenerative diseases, musculoskeletal disorders). Label: Joint Research Unit Research UMR) Main supervisory bodies: UM, Inserm Research cluster: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the organization WEBSITE

Infectious diseases are involved in 35% of deaths worldwide and are the leading cause of death among children and young adults. In addition, 17% of new cancer cases are believed to be caused by infectious agents. Research in infectious diseases is therefore essential to better understand how an infectious agent multiplies within a living organism in order to prevent, treat, and even cure the diseases caused by these infections. The IRIM (Montpellier Institute for Research Infectious Diseases) is a research center focused primarily on high-quality fundamental research in the fields of bacteriology, virology, and immunity. Label: Joint Research Unit Research UMR) Main supervisory bodies: CNRS, UMP Research pole: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the organization WEBSITE

The IRCM conducts cognitive, multidisciplinary, and applied research in the field of oncology. This research involves researchers and clinicians and aims to understand the different stages of tumorigenesis and, ultimately, to identify new diagnostic and therapeutic strategies for cancer. The Institute's unifying theme is "Molecular Targets and Cancer Therapy, Discovery, Biology, and Clinical Applications." The teams' projects are structured around two main areas: Therapeutic Antibodies in Oncology: innovation, engineering, biological response; Plasticity of solid tumors and their microenvironment: phenotypic and signaling pathway plasticity, genetic and epigenetic alterations, treatment resistance. Label: Joint Research Unit Research UMR) Main supervisory bodies: UM, Inserm, ICMP Research cluster: Biology and Health Doctoral schools: Information, Structures, Systems; Chemical and Biological Sciences for Health HAL portal: publications by the organization WEBSITE

The Montpellier Institute of Neuroscience aims to study the pathophysiology and therapies of sensory (hearing, vision, somesthesia) and motor deficits. In their research, the teams use multidisciplinary strategies such as molecular genetics, cellular imaging, and electrophysiology, as well as the study of integrated systems, to develop preclinical trials. The INM teams address a variety of research topics: Genetics and therapy of retinal blindness; Physiology and pathophysiology of the inner ear; Development and pathophysiology of proprioceptive systems; Physiology and therapeutic approaches to spinal cord pathologies. Label: Joint Research Unit Research UMR) Main supervisory bodies: UM, Inserm Research cluster: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the structure WEBSITE

Label: UR_UM103 Main supervisory bodies: UM, Nîmes University Hospital Research center: Biology and Health Doctoral schools: Chemical and Biological Sciences for Health; Information, Structures, Systems HAL portal: publications by the organization

The IGMM conducts cutting-edge, innovative fundamental research that may have implications in the fields of biomedicine and molecular and cellular medicine, particularly for treating cancer and certain infectious or genetic diseases. The IGMM has a long-standing, internationally recognized reputation in the disciplinary fields that constitute its main areas of research: RNA biology; gene regulation and epigenetics; Tumorigenesis/Cell Cycle and Death; Immunology/Virology/Biotherapies. In addition to these main areas, the IGMM is also driven by a cross-disciplinary approach involving mathematical/computational modeling and machine learning to better understand the pathophysiological phenomena at the heart of its scientific interests.Translational research is playing an increasingly important role in IGMM's research, with a growing number of hospital partnerships in Montpellier and beyond, and the inclusion of hospital practitioners in its teams. Label: Joint Research Unit Research UMR) Main supervisory bodies: CNRS, UMP Research pole: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the structure WEBSITE

The IGH conducts fundamental research of excellence and aims to apply its findings in the field of pathology. The main research topics concern genome and chromatin dynamics, developmental genetics, epigenetic control, and molecular and cellular pathologies. Three major areas of research have been established within the IGH: Genome dynamics and epigenetic control. The main aspects of this research concern DNA replication, maintenance of genome integrity, recombination and meiosis, retrotransposition and its control, chromatin and nuclear organization, gene expression regulation, and RNA silencing. Developmental genetics. This research relies heavily on model organisms such as Drosophila and transgenic mice. Topics include the cell cycle and microtubule dynamics, gonad development, RNA regulation in development, neurogenetics, and memory. Understanding, diagnosis, and treatment of human diseases. This work concerns DNA metabolism, epigenetic regulation and signaling pathways in cancer, the molecular basis of myogenesis, immunity, inflammatory diseases, AIDS, neurodegenerative diseases, and cell therapies. Label: Joint Research Unit Research UMR) Main supervisory bodies: CNRS, UMP Research pole: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the structure WEBSITE

The Institute of Functional Genomics (IGF) is a multidisciplinary research center. The IGF's main activity is dedicated to fundamental research based on functional genomics to explore normal and pathological processes of cellular signaling and communication in various fields, particularly neurobiology, cardiology, endocrinology, and oncology. Its main activities range from structural pharmacology to systems biology, from the development of preclinical disease models to translational research, with a view to studying various pathologies, including neurological and psychiatric diseases, cardiac dysfunction, diabetes, and cancer. One of the IGF's main objectives is to identify new concepts in molecular medicine and evaluate new strategies for the development of diagnostic and therapeutic tools. Label: Joint Research Unit Research UMR) Main supervisory bodies: CNRS, UM, Inserm Research cluster: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the organization WEBSITE

The Desbrest Institute of Epidemiology and Public Health (IDESP) aims to understand the development and progression of chronic diseases, which affect more than 30% of the population and account for 80% of healthcare spending. To do this, Research University of Montpellier Joint Research Unit uses a new approach that takes into account the broader environment and care pathways through multimodal markers (clinical, biological, behavioral, psychological, social, environmental) and draws on the power of mathematics dedicated to big data. Its purpose is to devise optimized care and prevention pathways for relevant patient targets. Allergic and respiratory diseases, diabetes, obesity, kidney and vascular diseases, inflammatory rheumatism, and cancers are the focus of the initial models. Label: Joint Research Unit Research UMR) Main supervisory bodies: UM, Inserm Research cluster: Biology and Health Doctoral schools: Information, Structures, Systems; Chemical and Biological Sciences for Health HAL portal: publications by the organization WEBSITE - HAL page

GENOPOLYS facilitates the organization of meetings, conferences, and workshops in the fields of biology and health, thanks to its meeting rooms, amphitheater, and two practical work rooms. GENOPOLYS is a hub for exchange, aimed at: the general public, with the aim of contributing to citizens' scientific and medical culture and participating in the science and society dialogue; researchers and doctors, by promoting the integration of clinical research into fundamental research; industrialists, with the aim of integrating the world of research into business through training, interaction, and development. Label: Support and Research Unit Research UAR) Main supervisory bodies: CNRS, UM, Inserm Research center: Biology and Health WEBSITE