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The research conducted by the LPHI teams aims to advance our understanding of biological membranes, particularly in the context of parasitic (malaria, toxoplasmosis), bacterial (tuberculosis, salmonellosis, staphylococcal infections), and viral (antiviral defenses) infectious processes. The LPHI unit prioritizes high-quality, innovative basic research in the field of biology. The research relies on integrated approaches combining genetics, molecular biology, biochemistry, structural biology, and in vitro and in vivo cell biology. The laboratory collaborates with chemists and hosts a team of theorists, physicists, and mathematicians to combine biology, chemistry, physics, and mathematics in comprehensive or targeted multidisciplinary approaches to the biological processes under study. Label: Joint Research Unit Research UMR)Main sponsoring organizations: CNRS, INSERM, UMPResearch cluster: Biology and HealthDoctoral schools: Information, Structures, Systems; Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

The goal of the Bioengineering and Nanoscience Laboratory’s research is to contribute to the application of nanoscience in the fields of health and biology, with a particular focus on dentistry. The primary goal is to advance nanomaterials and nanosensors toward clinical application using a high-quality methodological approach. Label: UR_UM104Primary affiliation: UMResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

The IRMB brings together scientists and clinicians involved in regenerative medicine and immunotherapies, encompassing both fundamental biology and innovative applications of regenerative therapy. The goal is to facilitate the transfer of stem cell biology research to clinical applications in coordination with clinicians specializing in chronic diseases (aging, rheumatoid arthritis, rare genetic diseases, diabetes, liver diseases, neurodegenerative diseases, musculoskeletal disorders). Label: Joint Research Unit Research UMR)Main sponsoring bodies: UM, InsermResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

Infectious diseases account for 35% of deaths worldwide and are the leading cause of death among children and young adults. Furthermore, it is estimated that 17% of new cancer cases are caused by infectious agents. Research in infectious diseases is therefore essential to better understand how an infectious agent multiplies within a living organism in order to prevent, treat, and even cure the diseases caused by these infections. The IRIM (Montpellier Institute for Research Infectious Diseases) is a research center focused primarily on high-quality basic research in the fields of bacteriology, virology, and immunity. Label: Joint Research Unit Research UMR)Main sponsoring bodies: CNRS, UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the institution WEBSITE

The IRCM conducts cognitive, multidisciplinary, and applied research in the field of oncology. This research involves researchers and clinicians and aims to understand the various stages of tumorigenesis and, ultimately, to identify new diagnostic and therapeutic strategies for cancer. The Institute’s overarching theme is “Molecular Targets and Cancer Therapy: Discovery, Biology, and Clinical Applications.” The teams’ projects focus on two key areas: Therapeutic Antibodies in Oncology: innovation, engineering, biological response; Plasticity of solid tumors and their microenvironment: phenotypic and signaling pathway plasticity, genetic and epigenetic alterations, treatment resistance. Label: Joint Research Unit Research UMR)Main sponsoring bodies: UM, Inserm, ICMResearch cluster: Biology and HealthDoctoral schools: Information, Structures, Systems; Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

The Montpellier Institute of Neuroscience aims to study the pathophysiology and treatments of sensory (hearing, vision, somatosensory) and motor deficits. In their research, the teams rely on multidisciplinary approaches—ranging from molecular genetics, cellular imaging, and electrophysiology to the study of integrated systems—to develop preclinical trials. The INM teams address various research topics: Genetics and therapy of retinal blindness; Physiology and pathophysiology of the inner ear; Development and pathophysiology of proprioceptive systems; Physiology and therapeutic approaches to spinal cord disorders. Label: Joint Research Unit Research UMR)Main sponsoring bodies: UM, InsermResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

Label: UR_UM103Primary affiliations: UM, Nîmes University HospitalResearch cluster: Biology and HealthDoctoral schools: Chemical and Biological Sciences for Health; Information, Structures, SystemsHAL portal: publications from this unit

The IGMM conducts innovative, world-class basic research with potential applications in the fields of biomedicine and molecular and cellular medicine, particularly in the treatment of cancer and certain infectious or genetic diseases. The IGMM has a long-standing, internationally recognized reputation in the disciplinary fields that constitute its main research areas: RNA Biology; Gene Regulation and Epigenetics; Tumorigenesis/Cell Cycle and Cell Death; Immunology/Virology/Biotherapies. In addition to these main areas, the IGMM is also driven by a cross-disciplinary approach involving mathematical/computational modeling and machine learning to better understand the pathophysiological phenomena at the heart of its scientific interests.Translational research plays an increasingly important role in IGMM’s research, with a growing number of hospital partnerships in and outside Montpellier and the inclusion of hospital practitioners in its teams. Label: Joint Research Unit Research UMR)Main sponsoring bodies: CNRS, UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

The IGH conducts cutting-edge basic research and aims to translate it into clinical applications in the field of pathology. The main research themes focus on genome and chromatin dynamics, developmental genetics, epigenetic regulation, and molecular and cellular pathologies. Three major research areas have been established within the IGH: Genome dynamics and epigenetic regulation. The main aspects of this research concern DNA replication, maintenance of genome integrity, recombination and meiosis, retrotransposition and its regulation, chromatin and nuclear organization, gene expression regulation, and RNA silencing. Developmental genetics. This research relies heavily on model organisms such as Drosophila and transgenic mice. Topics addressed include the cell cycle and microtubule dynamics, gonadal development, RNA regulation in development, neurogenetics, and memory. Understanding, diagnosis, and treatment of human diseases. This research focuses on DNA metabolism, epigenetic regulation and signaling pathways in cancer, the molecular basis of myogenesis, immunity, inflammatory diseases, AIDS, neurodegenerative diseases, and cell therapies. Label: Joint Research Unit Research UMR)Main sponsoring bodies: CNRS, UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

The Institute of Functional Genomics (IGF) is a multidisciplinary research center. The IGF’s primary focus is on basic research that leverages functional genomics to explore normal and pathological cellular signaling and communication processes across various fields, particularly in neurobiology, cardiology, endocrinology, and oncology. Its main activities range from structural pharmacology to systems biology, from the development of preclinical disease models to translational research, all aimed at studying various pathologies, including neurological and psychiatric disorders, cardiac dysfunction, diabetes, and cancer. One of the IGF’s main objectives is to identify new concepts in molecular medicine and evaluate new strategies for the development of diagnostic and therapeutic tools. Label: Joint Research Unit Research UMR)Main sponsoring bodies: CNRS, UM, InsermResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

The Desbrest Institute of Epidemiology and Public Health (IDESP) aims to understand the development and progression of chronic diseases, which affect more than 30% of the population and account for 80% of healthcare spending. To achieve this, Research University of Montpellier Joint Research Unit employs a new approach that takes into account the environment in the broadest sense and care trajectories through multimodal markers (clinical, biological, behavioral, psychological, social, and environmental), leveraging the power of mathematics dedicated to big data. Its goal is to design optimized care and prevention pathways for relevant patient populations. Allergic and respiratory diseases, diabetes, obesity, kidney and vascular diseases, inflammatory rheumatic diseases, and cancers form the basis of the initial modeling. Label: Joint Research Unit Research UMR)Main sponsoring bodies: UM, InsermResearch cluster: Biology and HealthDoctoral schools: Information, Structures, Systems; Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE - HAL page

GENOPOLYS offers facilities for meetings, conferences, and workshops—including meeting rooms, a lecture hall, and two laboratory spaces—in the fields of biology and health. GENOPOLYS serves as a hub for exchange, catering to: the general public, with the goal of contributing to citizens’ scientific and medical literacy and participating in the science-society dialogue;researchers and physicians, by promoting the integration of clinical research with basic research;industry professionals, with the goal of integrating the research community into the corporate world through training, interaction, and development. Label: Support and Research Unit Research UAR)Main sponsoring bodies: CNRS, UM, InsermResearch cluster: Biology and Health WEBSITE

The “EuroMov Digital Health in Motion” research unit aims to foster cross-fertilization between artificial intelligence, movement sciences, and health sciences to understand human behavioral plasticity, with the goal of improving sensorimotor performance and exploring new therapeutic approaches, while also identifying a scientific metaphor that can inspire new digital approaches: machine learning or adaptive control of complex systems, human-machine interaction, and context-aware software systems. https://youtu.be/xaUOKgoUwYI?list=PL6WmOx60MnJe_iazdaxlxc1zC3Mx1K3Z0 This line of research on “Digital Health in Motion” ultimately aims to better understand the etiology of human movement, considered as the level of integration of biological and cognitive phenomena, during our constant informational exchanges with the environment. The research unit is organized into three scientific themes and two cross-cutting areas: Theme: Perception In Action & Synchronization (PIAS): to uncover the laws governing human perception in moving agents (perception in action) and human-environment synchronization in general. Theme: Monitoring and Improving Behaviors (MIB): to provide users with guidance to improve their behaviors in order to achieve better health, quality of life, or athletic performance, with a particular focus on software engineering. The Learning and Complexity (LAC) theme focuses on the study of human learning and complexity through movement signatures, health data, and neural activity indicators, notably by developing interpretable models. Cross-cutting theme Semantics and Taxonomy of Movement (SemTaxM): identify taxonomic classifications of movement and define a theory of movement-based semantics and semantic models anchored in specific contexts. The cross-cutting theme Factory aims to improve the reproducibility of results and accelerate translational research and technology transfer by providing standardized and documented approaches with an open data dissemination strategy. Label: UR_UM102Primary Sponsors: UM, IMT Mines AlesResearch Cluster: Biology and HealthDoctoral Schools: Information, Structures, Systems; Human Movement SciencesHAL Portal: publications of the unit WEBSITE

The DMEM Laboratory is a joint research unit of INRA and the University of Montpellier. We are interested in understanding the tissue, cellular, and molecular mechanisms that enable skeletal muscles to develop properly and adapt to their environment. Our hypothesis is that abnormalities in the adaptation of muscle tissue to environmental changes (diet, level of physical activity) can affect the body’s homeostasis and, more broadly, overall health. The DMEM is therefore a fundamental research unit whose goal is to advance our understanding of the function and physiology of skeletal muscles. We are also open to potential applications of our research, as evidenced by our partnership with private companies interested in our findings. Label: Joint Research Unit Research UMR)Main Sponsors: UM, INRAEResearch Cluster: Biology and HealthDoctoral Schools: Human Movement Sciences; Chemical and Biological Sciences for HealthHAL Portal: publications of the unit WEBSITE

Label: Joint Research Unit Research UMR)Main sponsoring organizations: UM, Inserm, UPS ToulouseResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications from this unit WEBSITE

The Montpellier Center for Cell Biology Research is a laboratory of the CNRS and the University of Montpellier. The CRBM is internationally recognized in the field of molecular and cellular biology. Its research aims to understand the mechanisms controlling cell division, morphology, and adhesion under normal and pathological conditions, with a particular focus on cytoskeletal dynamics, post-translational modifications, and the intracellular signaling mechanisms regulating these cellular activities. Label: Joint Research Unit Research UMR)Main sponsoring bodies: CNRS, UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE