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The IGH conducts cutting-edge basic research and aims to advance it to the point of translating its findings into clinical applications in the field of pathology. The main research themes focus on genome and chromatin dynamics, developmental genetics, epigenetic regulation, and molecular and cellular pathologies. Three major research areas have been established within the IGH: Genome dynamics and epigenetic regulation. The main aspects of this research concern DNA replication, maintenance of genomic integrity, recombination and meiosis, retrotransposition and its regulation, chromatin and nuclear organization, gene expression regulation, and RNA silencing. Developmental genetics. This research relies heavily on model organisms such as Drosophila and transgenic mice. Topics addressed include the cell cycle and microtubule dynamics, gonadal development, RNA regulation in development, neurogenetics, and memory. Understanding, diagnosis, and treatment of human diseases. This research focuses on DNA metabolism, epigenetic regulation and signaling pathways in cancer, the molecular basis of myogenesis, immunity, inflammatory diseases, AIDS, neurodegenerative diseases, and cell therapies. Designation: Joint Research Unit ( Research , UMR)Primary sponsoring agencies: CNRS, UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: unit publications WEBSITE

The Institute of Functional Genomics (IGF) is a multidisciplinary research center. The IGF’s primary focus is on basic research that uses functional genomics to explore normal and pathological cellular signaling and communication processes in various fields, particularly neurobiology, cardiology, endocrinology, and oncology. Its main activities range from structural pharmacology to systems biology, and from the development of preclinical disease models to translational research, all aimed at studying various pathologies, including neurological and psychiatric disorders, cardiac dysfunction, diabetes, and cancer. One of the IGF’s main objectives is to identify new concepts in molecular medicine and evaluate new strategies for the development of diagnostic and therapeutic tools. Designation: Joint Research Unit ( Research , UMR)Primary sponsoring agencies: CNRS, UM, InsermResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: the unit’s publications WEBSITE

The Desbrest Institute of Epidemiology and Public Health (IDESP) aims to understand the development and progression of chronic diseases, which affect more than 30% of the population and account for 80% of healthcare spending. To achieve this, the INSERM–University of Montpellier Joint Research Unit ( Research ) employs a new approach that takes into account the environment in the broadest sense and care trajectories through multimodal markers (clinical, biological, behavioral, psychological, social, and environmental), drawing on the power of mathematics applied to big data. Its goal is to design optimized care and prevention pathways for relevant patient populations. Allergic and respiratory diseases, diabetes, obesity, kidney and vascular diseases, inflammatory rheumatic diseases, and cancers are the focus of the initial modeling efforts. Affiliation: Joint Research Unit ( Research , UMR)Primary Sponsors:UM, InsermResearch Cluster: Biology and HealthDoctoral Schools: Information, Structures, Systems; Chemical and Biological Sciences for HealthHAL Portal: publications by the unit WEBSITE - HAL Page

GENOPOLYS facilitates the organization of meetings, conferences, and workshops in the fields of biology and health through its meeting rooms, lecture hall, and two laboratory spaces. GENOPOLYS serves as a hub for exchange, catering to: the general public, with the goal of contributing to citizens’ scientific and medical literacy and fostering dialogue between science and society;researchers and physicians, by promoting the integration of clinical research with basic research;industry professionals, with the goal of integrating the research community into the business world through training, interaction, and development. Designation: Support and Research s Unit (UAR)Primary funding agencies: CNRS, UM, InsermResearch cluster: Biology and Health WEBSITE

The “EuroMov Digital Health in Motion” research unit aims to foster cross-fertilization among artificial intelligence, movement sciences, and health sciences to understand human behavioral plasticity, with the goal of improving sensorimotor performance and exploring new therapeutic approaches, while also identifying a scientific metaphor that serves as a source of inspiration for new digital approaches: machine learning or adaptive control of complex systems, human-machine interaction, and context-aware software systems. https://youtu.be/xaUOKgoUwYI?list=PL6WmOx60MnJe_iazdaxlxc1zC3Mx1K3Z0 This line of research on “Digital Health in Motion” ultimately aims to better understand the etiology of human movement—considered as the level of integration of biological and cognitive phenomena—during our constant exchange of information with the environment. The research unit is organized into three scientific themes and two cross-cutting areas: “Perception in Action & Synchronization” (PIAS) Theme: to uncover the laws governing human perception in moving agents (perception in action) and human-environment synchronization in general. “Monitoring and Improving Behaviors” (MIB) Theme: to provide users with guidance on improving their behaviors to achieve better health, quality of life, or athletic performance, with a particular focus on software engineering. The “Learning and Complexity” (LAC) theme focuses on the study of human learning and complexity through movement signatures related to health, clinical data, and indicators of neural activity, notably by developing interpretable models. Cross-cutting Area: Semantics and Taxonomy of Movement (SemTaxM): to identify taxonomic classifications of movement and define a theory of movement-based semantics and semantic models grounded in specific contexts. The cross-cutting research area “Factory” aims to improve the reproducibility of results and accelerate translational research and technology transfer by providing standardized and documented approaches, along with a strategy for open data dissemination. Label: UR_UM102Primary Affiliations: UM , IMT Mines AlèsResearch Cluster: Biology and HealthDoctoral Schools: Information, Structures, Systems; Human Movement SciencesHAL Portal: publications from the unit WEBSITE

The DMEM Laboratory is a joint research unit of INRA and the University of Montpellier. Our research focuses on understanding the tissue, cellular, and molecular mechanisms that enable skeletal muscles to develop properly and adapt to their environment. Our hypothesis is that abnormalities in the adaptation of muscle tissue to environmental changes (diet, physical activity levels) can affect the body’s homeostasis and, more broadly, overall health. The DMEM is therefore a basic research unit whose goal is to advance our understanding of the function and physiology of skeletal muscles. We are also open to potential applications of our research, as evidenced by our partnership with private companies interested in our findings. Label: Joint Research Unit ( Research , UMR)Primary funding agencies: UM , INRAEResearch cluster: Biology and HealthDoctoral schools: Human Movement Sciences; Chemical and Biological Sciences for HealthHAL portal: unit publications WEBSITE

Affiliation: Joint Research Unit ( Research , UMR) Main funding agencies:UM, Inserm, UPS Toulouse Research cluster: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by this institution WEBSITE

The Montpellier Center for Cell Biology Research is a laboratory of the CNRS and the University of Montpellier. The CRBM is internationally recognized in the field of molecular and cellular biology. Its research aims to understand the mechanisms governing cell division, morphology, and adhesion under normal and pathological conditions, with a particular focus on cytoskeletal dynamics, post-translational modifications, and the intracellular signaling mechanisms that regulate these cellular activities. Designation: Joint Research Unit ( Research , UMR)Primary sponsoring agencies: CNRS, UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: the unit’s publications WEBSITE

https://youtu.be/U-4QGKRe4wY Le CEMIPAI est un laboratoire de services du CNRS et de l’université de Montpellier, ouvert aux équipes académiques et aux entreprises. Il s’organise autour de l’un des plus grands laboratoires de sécurité microbiologie de niveau L3 de France, permettant de travailler en atmosphère contrôlée sur les prélèvements biologiques infectieux et les agents biologiques de classe 3, comme le virus de l’immunodéficience humaine (VIH), les virus des hépatites ou les virus transmis par les moustiques (Chikungunya, Dengue, Zika), les bactéries pathogènes et les prions. Le CEMIPAI accueille les équipes, forme les chercheurs à la manipulation des agents infectieux et développe des tests en cultures cellulaires permettant de rechercher des molécules d’intérêt thérapeutique développées par les chercheurs du privé et du public. Des équipements de pointe en microscopie super résolue permet d’observer cellules infectées, virus et bactéries à des échelles nanométriques. Label : Unité d’Appui et de Recherche (UAR)Tutelles principales : CNRS, UMPôle de recherche : Biologie SantéPortail HAL : publications de la structure SITE WEB

The CBS’s overall objective is to conduct cutting-edge research in structural biology, biophysics, and bioengineering to identify and characterize the fundamental mechanisms of life and their regulation across different scales of time and space (from single molecules to living tissues and organisms) using integrative approaches. We are particularly interested in understanding the molecular and physical determinants of these processes using state-of-the-art methodologies. We believe that achieving these objectives requires studying the structure and dynamics of supramolecular assemblies at different scales, as well as gaining a detailed understanding of their assembly and regulatory mechanisms. Furthermore, our ambition is to study these processes in more integrated contexts, such as living cells or model organisms. Whenever possible, we also apply this knowledge to develop new therapeutic strategies for human health and disease. Label: Joint Research Unit ( Research , UMR)Primary Sponsors: CNRS, UM, InsermResearch Cluster: Biology and HealthDoctoral Schools: Information, Structures, Systems; Chemical and Biological Sciences for HealthHAL Portal: the unit’s publications WEBSITE

BioCampus Montpellier is a federative research organization that brings together 12 high-level technology platforms. These platforms serve a scientific community of 2,000 Professors , most of whose teams belong to the AGRO, CeMEB, and EpiGenMed Labex programs. The UMS offers its services to researchers in these units as well as to industry partners with the goal of building new collaborative networks. Its platforms offer “open-access” services, scientific and technical expertise, training in the form of technology workshops, and more. Thematic Areas: Bioinformatics, Structural Biology, Cell Culture and Functional Screening, Histology, Imaging, Small Animal Imaging, Molecular Combing, Recombinant Proteins, Genomics, Pharmacology, Proteomics, Vectorology. Designation: Support and Research s Unit (UAR)Primary governing bodies: CNRS, UM, InsermResearch cluster: Biology and HealthHAL portal: the unit’s publications WEBSITE

Our unit’s research focuses on biocommunication between the cardiovascular/renal axis and metabolic tissues within the complex pathophysiological context of metabolic syndrome. Our research aims to better characterize the pathophysiological mechanisms involved in damage to various target tissues (cardiovascular and metabolic) during metabolic dysfunction, as well as the bio-communication pathways between these tissues. Through this integrative approach to chronic diseases, we hope to develop new therapeutic strategies aimed at preventing damage to cardiovascular and metabolic tissues and thereby reducing cardiovascular risk and metabolic dysfunction. Label: UR_UM101Primary affiliation: UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications from this unit WEBSITE

The mission of the Sciences for Oenology unit is to conduct general research in plant biology, microbiology, biochemistry, chemistry, and physical chemistry, with a primary focus on the viticulture and winemaking sector. Researchers in the unit focus primarily on topics related to: The integrative physiology of oenological yeasts and the control of alcoholic fermentation; Phenolic compounds (biosynthesis, reactivity, physicochemical interactions, properties, and utilization). Designation: Joint Research Unit ( Research , UMR)Primary Sponsors: UM, INRAE, Institut AgroResearch Cluster: Agriculture-Environment-Biodiversity (AEB)Doctoral School: Biodiversity, Agriculture, Food, Environment, Land, WaterHAL Portal: the unit’s publications WEBSITE

The QualiSud unit conducts scientific research aimed at analyzing, understanding, and optimizing the process of building food quality throughout the processing chain. Particular attention is given to sensory quality, health effects, and health risks. The research activities of the QualiSud Joint Research Unit (UMR) are structured around five scientific areas: process bioguidance based on sensory qualities and food safety; control of post-harvest quality in fresh fruits and vegetables; strategies for the prevention and control of mycotoxins throughout the food supply chain; study of mass transfer and reaction kinetics during the fermentation of solid foods; multicriteria analysis and design to support decision-making in the agri-food sector. Affiliation: Joint Research Unit ( Research , UMR) Main funding agencies: UM , CIRAD, IRD, Institut Agro, U RÉUNION, UAPV Research cluster: Agriculture, Environment, Biodiversity – AEBE Doctoral school: Biodiversity, Agriculture, Food, Environment, Land, Water HAL portal: publications by the unit WEBSITE

Numerous interactions occur between the various micro- and macro-organisms in agroecosystems and plants. These interactions, which determine plant health, growth, and productivity, are often poorly understood. The PHIM Joint Research Unit (UMR) generates knowledge and solutions to improve plant health and increase plant productivity and quality. PHIM uses approaches from molecular biology and genetics, population genetics and genomics, epidemiology, and population dynamics and modeling to study these interactions at scales ranging from the cellular level to the crop plot. Label: Joint Research Unit ( Research , UMR)Primary sponsoring institutions: CIRAD, INRAE, IRD, Institut AgroSecondary sponsoring institution: UMResearch cluster: Agriculture, Environment, Biodiversity – AEBDoctoral school: Biodiversity, Agriculture, Food, Environment, Earth, WaterHAL portal: the unit’s publications WEBSITE

OREME focuses its scientific activities on natural hazards and the impact of global and anthropogenic changes on the Mediterranean region, drawing on the scientific and technical expertise of its partners in the geosciences, hydrosciences, biodiversity sciences, and ecology. Its mission is: to support the conduct or development of systematic observation in space and environmental sciences; to support the creation of open, shared, and internationally referenced environmental databases; to encourage the pooling of analytical resources (observation, experimentation, modeling) and expertise; to serve as the local liaison for national observation networks and to position itself as a key player in Mediterranean-focused environmental initiatives. OREME therefore focuses on three fundamental questions: the origin and assessment of natural and human-induced hazards and disturbances; the documentation of recent and ongoing global changes, their links to human factors, and in particular changes in the use of Mediterranean environments; the response of the systems and mechanisms involved. Drawing on the educational programs of the University of Montpellier to fulfill its educational mission, OREME focuses on its ability to mobilize extensive and sustainable observation resources, as well as recognized scientific and technical expertise, on a wide range of aspects of the Mediterranean’s physical, chemical, and biological environment: geodesy, gravimetry, and deformation of the Earth and its surface; hydrogeological, hydrological, and geophysical monitoring of aquifers, particularly karstic ones; monitoring of the Languedoc coastline, the interface between watersheds and marine environments, and the shoreline; pollution and biological resilience downstream of former mining sites; measurement of fluxes (CO₂, water, gases) and ecosystem functioning; phenology of terrestrial flora and fauna; dynamics of animal and plant communities; population dynamics of model organisms. It also houses three major regional technical platforms: GLADYS for integrated coastal studies, AETE for water pollution analysis, and the Sète Marine Station (SMEL). OREME’s continuous monitoring enables the collection and dissemination of data on environmental change at the national and international levels, as well as the conduct of basic and applied research. Designation: Support and Research s Unit (UAR)Primary funding agencies: CNRS, UM, INRAE, IRDResearch cluster: Agriculture, Environment, Biodiversity – AEBHAL portal: the unit’s publications WEBSITE