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The IGMM conducts cutting-edge, innovative fundamental research that may have implications in the fields of biomedicine and molecular and cellular medicine, particularly for treating cancer and certain infectious or genetic diseases. The IGMM has a long-standing, internationally recognized reputation in the disciplinary fields that constitute its main areas of research: RNA biology; gene regulation and epigenetics; Tumorigenesis/Cell Cycle and Death; Immunology/Virology/Biotherapies. In addition to these main areas, the IGMM is also driven by a cross-disciplinary approach involving mathematical/computational modeling and machine learning to better understand the pathophysiological phenomena at the heart of its scientific interests.Translational research is playing an increasingly important role in IGMM's research, with a growing number of hospital partnerships in Montpellier and beyond, and the inclusion of hospital practitioners in its teams. Label: Joint Research Unit Research UMR) Main supervisory bodies: CNRS, UMP Research pole: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the structure WEBSITE

The IGH conducts fundamental research of excellence and aims to apply its findings in the field of pathology. The main research topics concern genome and chromatin dynamics, developmental genetics, epigenetic control, and molecular and cellular pathologies. Three major areas of research have been established within the IGH: Genome dynamics and epigenetic control. The main aspects of this research concern DNA replication, maintenance of genome integrity, recombination and meiosis, retrotransposition and its control, chromatin and nuclear organization, gene expression regulation, and RNA silencing. Developmental genetics. This research relies heavily on model organisms such as Drosophila and transgenic mice. Topics include the cell cycle and microtubule dynamics, gonad development, RNA regulation in development, neurogenetics, and memory. Understanding, diagnosis, and treatment of human diseases. This work concerns DNA metabolism, epigenetic regulation and signaling pathways in cancer, the molecular basis of myogenesis, immunity, inflammatory diseases, AIDS, neurodegenerative diseases, and cell therapies. Label: Joint Research Unit Research UMR) Main supervisory bodies: CNRS, UMP Research pole: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the structure WEBSITE

The Institute of Functional Genomics (IGF) is a multidisciplinary research center. The IGF's main activity is dedicated to fundamental research based on functional genomics to explore normal and pathological processes of cellular signaling and communication in various fields, particularly neurobiology, cardiology, endocrinology, and oncology. Its main activities range from structural pharmacology to systems biology, from the development of preclinical disease models to translational research, with a view to studying various pathologies, including neurological and psychiatric diseases, cardiac dysfunction, diabetes, and cancer. One of the main objectives of the IGF is to identify new concepts in molecular medicine and evaluate new strategies for the development of diagnostic and therapeutic tools. Label: Joint Research Unit Research UMR) Main supervisory bodies: CNRS, UM, Inserm Research cluster: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the organization WEBSITE

The Desbrest Institute of Epidemiology and Public Health (IDESP) aims to understand the development and progression of chronic diseases, which affect more than 30% of the population and account for 80% of healthcare spending. To do this, Research University of Montpellier Joint Research Unit uses a new approach that takes into account the broader environment and care pathways through multimodal markers (clinical, biological, behavioral, psychological, social, environmental) and draws on the power of mathematics dedicated to big data. Its aim is to devise optimized care and prevention pathways for relevant patient targets. Allergic and respiratory diseases, diabetes, obesity, kidney and vascular diseases, inflammatory rheumatism, and cancers are the focus of the initial modeling. Label: Joint Research Unit Research UMR) Main supervisory bodies: UM, Inserm Research cluster: Biology and Health Doctoral schools: Information, Structures, Systems; Chemical and Biological Sciences for Health HAL portal: publications by the organization WEBSITE - HAL page

GENOPOLYS facilitates the organization of meetings, conferences, and workshops in the fields of biology and health thanks to its meeting rooms, amphitheater, and two practical work rooms. GENOPOLYS is a hub for exchange, aimed at: the general public, with the aim of contributing to citizens' scientific and medical culture and participating in the science and society dialogue; researchers and doctors, by promoting the integration of clinical research into fundamental research; industrialists, with the aim of integrating the world of research into business through training, interaction, and development. Label: Support and Research Unit Research UAR) Main supervisory bodies: CNRS, UM, Inserm Research center: Biology and Health WEBSITE

The EuroMov Digital Health in Motion research unit aims to promote cross-fertilization between artificial intelligence, movement sciences, and health in order to understand human behavioral plasticity, improve sensorimotor performance, and explore new therapeutic approaches. It also seeks to find a scientific metaphor that can inspire new digital approaches: machine learning or adaptive control of complex systems, human/machine interaction, and context-sensitive software systems. https://youtu.be/xaUOKgoUwYI?list=PL6WmOx60MnJe_iazdaxlxc1zC3Mx1K3Z0 This line of research on "Digital Health in Motion" ultimately aims to better understand the etiology of human movement, considered as the level of integration of biological and cognitive phenomena, during our constant informational exchanges with the environment. The research unit is organized into three scientific themes and two cross-cutting areas: Perception In Action & Synchronization (PIAS) theme: discovering the laws governing human perception in moving agents (perception in action) and human-environment synchronization in general. Monitoring and Improving Behaviors (MIB) theme: providing users with advice on how to improve their behaviors in order to achieve better health, quality of life, or athletic performance, with a particular focus on software engineering. The Learning and Complexity (LAC) theme focuses on the study of human learning and complexity through movement signatures, health data, and neural activity indicators, with a particular emphasis on developing interpretable models. Cross-disciplinary Semantics and Taxonomy of Movement (SemTaxM): identifying taxonomic classifications of movement and defining a theory of movement-based semantics and semantic models anchored in specific contexts. The Factory cross-disciplinary focus aims to improve the reproducibility of results and accelerate translational research and technology transfer by providing standardized and documented approaches with an open data dissemination strategy. Label: UR_UM102 Main supervisory bodies: UM, IMT Mines Ales Research cluster: Biology and Health Doctoral schools: Information, Structures, Systems; Human Movement Sciences HAL portal: publications by the structure WEBSITE

The DMEM laboratory is a joint research unit of INRA and the University of Montpellier. We are interested in understanding the tissue, cellular, and molecular mechanisms that enable skeletal muscles to develop properly and adapt to their environment. Our hypothesis is that abnormalities in the adaptation of muscle tissue to environmental changes (diet, level of physical activity) can modulate the body's homeostasis and, more broadly, its state of health. The DMEM is therefore a fundamental research unit whose goal is to advance our knowledge of the functioning and physiology of skeletal muscles. We are also open to possible applications of our research, as evidenced by our partnership with private companies interested in our results. Label: Joint Research Unit Research UMR) Main supervisory bodies: UM, INRA Research cluster: Biology and Health Doctoral schools: Human Movement Sciences; Chemical and Biological Sciences for Health HAL portal: publications by the unit WEBSITE

Label: Joint Research Unit Research UMR) Main supervisory bodies: UM, Inserm, UPS Toulouse Research cluster: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the organization WEBSITE

The Montpellier Cell Biology Research Center is a laboratory of the CNRS and the University of Montpellier. The CRBM is internationally recognized in the field of molecular and cellular biology. Its research activity aims to understand the mechanisms controlling cell division, morphology, and adhesion under normal and pathological conditions, with a particular focus on cytoskeletal dynamics, post-translational modifications, and intracellular signaling mechanisms regulating these cellular activities. Label: Joint Research Unit Research UMR) Main supervisory bodies: CNRS, UMP Research pole: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the structure WEBSITE

https://youtu.be/U-4QGKRe4wY Le CEMIPAI est un laboratoire de services du CNRS et de l’université de Montpellier, ouvert aux équipes académiques et aux entreprises. Il s’organise autour de l’un des plus grands laboratoires de sécurité microbiologie de niveau L3 de France, permettant de travailler en atmosphère contrôlée sur les prélèvements biologiques infectieux et les agents biologiques de classe 3, comme le virus de l’immunodéficience humaine (VIH), les virus des hépatites ou les virus transmis par les moustiques (Chikungunya, Dengue, Zika), les bactéries pathogènes et les prions. Le CEMIPAI accueille les équipes, forme les chercheurs à la manipulation des agents infectieux et développe des tests en cultures cellulaires permettant de rechercher des molécules d’intérêt thérapeutique développées par les chercheurs du privé et du public. Des équipements de pointe en microscopie super résolue permet d’observer cellules infectées, virus et bactéries à des échelles nanométriques. Label : Unité d’Appui et de Recherche (UAR)Tutelles principales : CNRS, UMPôle de recherche : Biologie SantéPortail HAL : publications de la structure SITE WEB

The overall objective of CBS is to conduct cutting-edge research in structural biology, biophysics, and bioengineering to identify and characterize the fundamental mechanisms of life and their regulation, at different scales of time and space (from single molecules to living tissues and organisms) and using integrative approaches. We are particularly interested in understanding the molecular and physical determinants of these processes using state-of-the-art methodologies. We believe that the answer to these objectives involves studying the structure and dynamics of supramolecular assemblies at different scales, as well as a detailed understanding of their assembly and regulatory mechanisms. In addition, our ambition is to study these processes in more integrated contexts such as living cells or model organisms. Where possible, we also exploit this knowledge to design new therapeutic strategies for human health and disease. Label: Joint Research Unit Research UMR) Main supervisory bodies: CNRS, UM, Inserm Research cluster: Biology and Health Doctoral schools: Information, Structures, Systems; Chemical and Biological Sciences for Health HAL portal: publications by the organization WEBSITE

BioCampus Montpellier is a federative research structure that brings together 12 high-level technology platforms. These platforms serve a scientific community of 2,000 Professors most Professors teams belong to the AGRO, CeMEB, and EpiGenMed labexes. The UMS offers its services to research units as well as industrialists with the aim of establishing new collaborative networks. Its platforms offer "open access" services, scientific and technical expertise, training in the form of technology workshops, etc. Themes: Bioinformatics, Structural Biology, Breeding and Functional Exploration, Histology, Imaging, Small Animal Imaging, Molecular Combing, Recombinant Proteins, Genomics, Pharmacology, Proteomics, Vectorology. Label: Support and Research Unit Research UAR) Main supervisory bodies: CNRS, UM, Inserm Research cluster: Biology and Health HAL portal: publications by the organization WEBSITE

Our unit's project focuses on biocommunication between the cardiovascular/renal axis and metabolic tissues in a complex pathophysiological context, namely metabolic syndrome. Our work aims to better characterize the pathophysiological mechanisms involved in damage to different target tissues (cardiovascular and metabolic) during metabolic dysfunction, as well as the biocommunication pathways between these tissues. Through this integrative approach to chronic diseases, we hope to develop new therapeutic strategies with the aim of preventing damage to cardiovascular and metabolic tissues and thus reducing cardiovascular risk and metabolic dysfunction. Label: UR_UM101 Main supervisory body: UMP Research center: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: publications by the organization WEBSITE

The mission of the Sciences for Oenology unit is to develop generic research in plant biology, microbiology, biochemistry, chemistry, and physical chemistry, with a primary focus on the wine industry. Researchers in the unit concentrate mainly on topics related to: The integrative physiology of oenological yeasts and the control of alcoholic fermentation; Phenolic compounds (biosynthesis, reactivity, physicochemical interactions, properties, valorization). Label: Joint Research Unit Research UMR) Main supervisory bodies: UM, INRAE, Institut AgroPôle de recherche: Agriculture-Environment-Biodiversity Cluster (AEB) Doctoral school: Biodiversity, Agriculture, Food, Environment, Earth, Water HAL portal: publications by the organization WEBSITE

The QualiSud unit develops scientific activities aimed at analyzing, understanding, and optimizing the process of building food quality throughout the processing chain. Sensory quality, health effects, and health risks are given particular attention. The research activities of the QualiSud joint research unit are structured around five scientific areas: bioguiding of processes based on the sensory qualities and health benefits of food; control of post-harvest quality of fresh fruit and vegetables; strategies for the prevention and control of mycotoxins throughout the food chain; study of transfers and reaction kinetics during the fermentation of solid foods; multi-criteria analysis and design for decision support in the agri-food industry. Label: Joint Research Unit Research UMR) Main supervisory bodies: UM, CIRAD, IRD, Institut Agro, U RÉUNION, UAPV Research cluster: Agriculture, Environment, Biodiversity – AEB Doctoral school: Biodiversity, Agriculture, Food, Environment, Earth, Water HAL portal: publications by the organization WEBSITE

Numerous interactions take place between the various micro- and macro-organisms in agro-ecosystems and plants. These interactions, which determine plant health, growth, and productivity, are often poorly understood. The PHIM joint research unit produces knowledge and solutions to improve plant health and increase their productivity and quality. PHIM uses approaches from molecular biology and genetics, population genetics and genomics, epidemiology, and population dynamics and modeling to study these interactions at scales ranging from the cell to the cultivated plot. Label: Joint Research Unit Research UMR) Main supervisory bodies: CIRAD, INRAE, IRD, Institut Agro Secondary supervisory body: UMP Research cluster: Agriculture, Environment, Biodiversity – AEB Doctoral school: Biodiversity, Agriculture, Food, Environment, Earth, Water HAL portal: publications by the organization WEBSITE