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The IGH conducts cutting-edge basic research and aims to translate it into clinical applications in the field of pathology. The main research themes focus on genome and chromatin dynamics, developmental genetics, epigenetic regulation, and molecular and cellular pathologies. Three major research areas have been established within the IGH: Genome dynamics and epigenetic regulation. The main aspects of this research concern DNA replication, maintenance of genome integrity, recombination and meiosis, retrotransposition and its regulation, chromatin and nuclear organization, gene expression regulation, and RNA silencing. Developmental genetics. This research relies heavily on model organisms such as Drosophila and transgenic mice. Topics addressed include the cell cycle and microtubule dynamics, gonadal development, RNA regulation in development, neurogenetics, and memory. Understanding, diagnosis, and treatment of human diseases. This work focuses on DNA metabolism, epigenetic regulation and signaling pathways in cancer, the molecular basis of myogenesis, immunity, inflammatory diseases, AIDS, neurodegenerative diseases, and cell therapies. Label: Joint Research Unit Research UMR)Main sponsoring bodies: CNRS, UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

The Institute of Functional Genomics (IGF) is a multidisciplinary research center. The IGF’s primary focus is on basic research that leverages functional genomics to explore normal and pathological cellular signaling and communication processes across various fields, particularly in neurobiology, cardiology, endocrinology, and oncology. Its main activities range from structural pharmacology to systems biology, from the development of preclinical disease models to translational research, all aimed at studying various pathologies, including neurological and psychiatric disorders, cardiac dysfunction, diabetes, and cancer. One of the IGF’s main objectives is to identify new concepts in molecular medicine and evaluate new strategies for the development of diagnostic and therapeutic tools. Label: Joint Research Unit Research UMR)Main sponsoring organizations: CNRS, UM, InsermResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

The Desbrest Institute of Epidemiology and Public Health (IDESP) aims to understand the development and progression of chronic diseases, which affect more than 30% of the population and account for 80% of healthcare spending. To achieve this, Research University of Montpellier Joint Research Unit employs a new approach that takes into account the environment in the broadest sense and care pathways through multimodal markers (clinical, biological, behavioral, psychological, social, and environmental), leveraging the power of mathematics dedicated to big data. Its goal is to design optimized care and prevention pathways for relevant patient populations. Allergic and respiratory diseases, diabetes, obesity, kidney and vascular diseases, inflammatory rheumatic diseases, and cancers form the basis of the initial models. Label: Joint Research Unit Research UMR)Main sponsoring bodies:UM, InsermResearch cluster: Biology and HealthDoctoral schools: Information, Structures, Systems; Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE - HAL page

GENOPOLYS provides facilities for meetings, conferences, and workshops in the fields of biology and health, thanks to its meeting rooms, lecture hall, and two laboratory spaces. GENOPOLYS serves as a hub for exchange, catering to: the general public, with the goal of contributing to citizens’ scientific and medical literacy and fostering dialogue between science and society;researchers and physicians, by promoting the integration of clinical research with basic research;industry professionals, with the goal of integrating the research community into the corporate world through training, interaction, and development. Label: Support and Research Unit Research UAR)Main sponsoring organizations: CNRS, UM, InsermResearch cluster: Biology and Health WEBSITE

The “EuroMov Digital Health in Motion” research unit aims to foster cross-fertilization between artificial intelligence, movement sciences, and health to understand human behavioral plasticity, with the goal of improving sensorimotor performance and exploring new therapeutic approaches, while also identifying a scientific metaphor that can inspire new digital approaches: machine learning or adaptive control of complex systems, human-machine interaction, and context-aware software systems. https://youtu.be/xaUOKgoUwYI?list=PL6WmOx60MnJe_iazdaxlxc1zC3Mx1K3Z0 This line of research on “Digital Health in Motion” ultimately aims to better understand the etiology of human movement, considered as the level of integration of biological and cognitive phenomena, during our constant informational exchanges with the environment. The research unit is organized into three scientific themes and two cross-cutting areas: Theme: Perception In Action & Synchronization (PIAS): to uncover the laws governing human perception in moving agents (perception in action) and human-environment synchronization in general. Theme: Monitoring and Improving Behaviors (MIB): to provide users with guidance to improve their behaviors in order to achieve better health, quality of life, or athletic performance, with a particular focus on software engineering. The Learning and Complexity (LAC) theme focuses on the study of human learning and complexity through movement signatures, health data, and neural activity indicators, notably by developing interpretable models. Cross-cutting theme Semantics and Taxonomy of Movement (SemTaxM): identify taxonomic classifications of movement and define a theory of movement-based semantics and semantic models grounded in specific contexts. The cross-cutting theme Factory aims to improve the reproducibility of results and accelerate translational research and technology transfer by providing standardized and documented approaches with an open data dissemination strategy. Label: UR_UM102Primary affiliations:UM, IMT Mines AlèsResearch cluster: Biology and HealthDoctoral schools: Information, Structures, Systems; Human Movement SciencesHAL portal: publications of the unit WEBSITE

The DMEM Laboratory is a joint research unit of INRA and the University of Montpellier. We are interested in understanding the tissue, cellular, and molecular mechanisms that enable skeletal muscles to develop properly and adapt to their environment. Our hypothesis is that abnormalities in the adaptation of muscle tissue to environmental changes (diet, level of physical activity) can affect the body’s homeostasis and, more broadly, overall health. The DMEM is therefore a basic research unit whose goal is to advance our understanding of the function and physiology of skeletal muscles. We are also open to potential applications of our research, as evidenced by our partnership with private companies interested in our findings. Label: Joint Research Unit Research UMR)Main sponsoring institutions:UM, INRAEResearch cluster: Biology and HealthDoctoral schools: Human Movement Sciences; Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

Label: Joint Research Unit Research UMR)Main sponsoring organizations:UM, Inserm, UPS ToulouseResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: the unit’s publications WEBSITE

The Montpellier Center for Cell Biology Research is a laboratory affiliated with the CNRS and the University of Montpellier. The CRBM is internationally recognized in the field of molecular and cellular biology. Its research aims to understand the mechanisms controlling cell division, morphology, and adhesion under normal and pathological conditions, with a particular focus on cytoskeletal dynamics, post-translational modifications, and the intracellular signaling mechanisms regulating these cellular activities. Label: Joint Research Unit Research UMR)Main sponsoring bodies: CNRS, UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

https://youtu.be/U-4QGKRe4wY Le CEMIPAI est un laboratoire de services du CNRS et de l’université de Montpellier, ouvert aux équipes académiques et aux entreprises. Il s’organise autour de l’un des plus grands laboratoires de sécurité microbiologie de niveau L3 de France, permettant de travailler en atmosphère contrôlée sur les prélèvements biologiques infectieux et les agents biologiques de classe 3, comme le virus de l’immunodéficience humaine (VIH), les virus des hépatites ou les virus transmis par les moustiques (Chikungunya, Dengue, Zika), les bactéries pathogènes et les prions. Le CEMIPAI accueille les équipes, forme les chercheurs à la manipulation des agents infectieux et développe des tests en cultures cellulaires permettant de rechercher des molécules d’intérêt thérapeutique développées par les chercheurs du privé et du public. Des équipements de pointe en microscopie super résolue permet d’observer cellules infectées, virus et bactéries à des échelles nanométriques. Label : Unité d’Appui et de Recherche (UAR)Tutelles principales : CNRS, UMPôle de recherche : Biologie SantéPortail HAL : publications de la structure SITE WEB

The CBS’s overarching goal is to conduct cutting-edge research in structural biology, biophysics, and bioengineering to identify and characterize the fundamental mechanisms of life and their regulation across different temporal and spatial scales (from individual molecules to living tissues and organisms) using integrative approaches. We are particularly interested in understanding the molecular and physical determinants of these processes using state-of-the-art methodologies. We believe that achieving these objectives involves studying the structure and dynamics of supramolecular assemblies at different scales, as well as gaining a detailed understanding of their assembly and regulatory mechanisms. Furthermore, our ambition is to study these processes in more integrated contexts such as living cells or model organisms. Where possible, we also apply this knowledge to design new therapeutic strategies for human health and disease. Label: Joint Research Unit Research UMR)Main sponsoring organizations: CNRS, UM, InsermResearch cluster: Biology and HealthDoctoral schools: Information, Structures, Systems; Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

BioCampus Montpellier is a research consortium comprising 12 high-level technology platforms. These platforms serve a scientific community of 2,000 Professors most Professors teams are affiliated with the AGRO, CeMEB, and EpiGenMed Labex programs. The UMS offers its services to members of the research units as well as to industry partners with the aim of establishing new collaborative networks. Its platforms offer “open access” services, scientific and technical expertise, training in the form of technology workshops, and more. Themes: Bioinformatics, Structural Biology, Functional Screening and Exploration, Histology, Imaging, Small Animal Imaging, Molecular Combing, Recombinant Proteins, Genomics, Pharmacology, Proteomics, Vectorology. Label: Support and Research Unit Research UAR)Main funding bodies: CNRS, UM, InsermResearch cluster: Biology and HealthHAL portal: the unit’s publications WEBSITE

Our research unit focuses on the bio-communication between the cardiovascular/renal axis and metabolic tissues within the complex pathophysiological context of metabolic syndrome. Our work aims to better characterize the pathophysiological mechanisms involved in the damage to various target tissues (cardiovascular and metabolic) during metabolic dysfunction, as well as the bio-communication pathways between these tissues. Through this integrative approach to chronic diseases, we hope to develop new therapeutic strategies aimed at preventing damage to cardiovascular and metabolic tissues, thereby reducing cardiovascular risk and metabolic dysfunction. Label: UR_UM101Primary affiliation: UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications of the unit WEBSITE

The mission of the Sciences for Oenology unit is to conduct fundamental research in plant biology, microbiology, biochemistry, chemistry, and physical chemistry, with a primary focus on the viticulture and winemaking sector. The unit’s researchers concentrate primarily on the following areas: The integrative physiology of oenological yeasts and the control of alcoholic fermentation; Phenolic compounds (biosynthesis, reactivity, physicochemical interactions, properties, and utilization). Label: Joint Research Unit Research UMR)Main sponsoring bodies: UM, INRAE, Institut AgroResearch cluster: Agriculture-Environment-Biodiversity (AEB)Doctoral school: Biodiversity, Agriculture, Food, Environment, Land, WaterHAL portal: unit publications WEBSITE

The QualiSud unit conducts scientific research aimed at analyzing, understanding, and optimizing the process of building food quality throughout the processing chain. Sensory quality, health effects, and health risks are given particular attention. The research activities of the QualiSud UMR are structured around five scientific areas: process bioguidance based on sensory qualities and food safety; control of post-harvest quality in fresh fruits and vegetables; strategies for the prevention and control of mycotoxins throughout the food supply chain; study of mass transfer and reaction kinetics during the fermentation of solid foods; multi-criteria analysis and design for decision support in the agri-food sector. Label: Joint Research Unit Research UMR)Main sponsoring organizations:UM, CIRAD, IRD, Institut Agro, U RÉUNION, UAPVResearch cluster: Agriculture, Environment, Biodiversity – AEBDoctoral school: Biodiversity, Agriculture, Food, Environment, Land, WaterHAL portal: publications of the unit WEBSITE

Numerous interactions occur between the various micro- and macro-organisms in agroecosystems and plants. These interactions, which determine plant health, growth, and productivity, are often poorly understood. The PHIM Joint Research Unit (UMR) generates knowledge and solutions to improve plant health and increase plant productivity and quality. PHIM uses approaches from molecular biology and genetics, population genetics and genomics, epidemiology, and population dynamics and modeling to study these interactions at scales ranging from the cellular level to the crop field. Label: Joint Research Unit Research UMR)Primary sponsors: CIRAD, INRAE, IRD, Institut AgroSecondary sponsor: UMResearch cluster: Agriculture, Environment, Biodiversity – AEBDoctoral school: Biodiversity, Agriculture, Food, Environment, Earth, WaterHAL portal: unit publications WEBSITE

OREME focuses its scientific activities on natural hazards and the impact of global and anthropogenic changes on the Mediterranean region, drawing on the scientific and technical expertise of its partners in geosciences, hydrosciences, biodiversity sciences, and ecology. Its mission is: to support the implementation or development of systematic observation in space and environmental sciences; to support the construction of open, shared environmental databases that are internationally referenced; to encourage the pooling of analytical resources (observation, experimentation, modeling) and expertise; to serve as the local hub for national observation networks and position itself as a key player in Mediterranean-focused environmental initiatives. OREME therefore focuses on three fundamental questions: the origin and assessment of natural and anthropogenic hazards and disturbances; the recording of recent and current global changes, their links to anthropogenic factors, and in particular changes in the use of Mediterranean environments; the response of the systems and mechanisms involved. Drawing on the educational resources of the University of Montpellier for its educational mission, OREME focuses on its ability to mobilize extensive and sustainable observation resources and recognized scientific and technical expertise on a wide range of aspects of the Mediterranean’s physical, chemical, and biological environment: geodesy, gravimetry, and deformation of the Earth and its surface; hydrogeological, hydrological, and geophysical monitoring of aquifers, particularly karstic ones; monitoring of the Languedoc coastline, the interface between the watershed and the marine environment, and the shoreline; pollution and biological adaptability downstream of former mining sites; flux measurements (CO2, water, gases) and ecosystem functioning; phenology of terrestrial flora and fauna; dynamics of animal and plant communities; population dynamics of model organisms. It also houses three major regional technical platforms: GLADYS for integrated coastal studies, AETE for water pollution analysis, and the Sète Marine Station (SMEL). OREME’s continuous observation enables the collection and dissemination of data on environmental change at the national and international levels, as well as the conduct of fundamental and applied research. Label: Support and Research Unit Research UAR)Main funding bodies: CNRS, UM, INRAE, IRDResearch cluster: Agriculture, Environment, Biodiversity – AEBHAL portal: publications of the unit WEBSITE