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The Bacterial Virulence and Chronic Infections Laboratory (VBIC) (University of Montpellier, INSERM) was established on January 1, 2011, and is located at the Faculty of Medicine and Health Sciences in Nîmes. Since January 2023, the “Staphylococcal Infection Biology Project Team,” located at the Triolet Campus in Montpellier, has joined the VBIC. We take a “bench-to-bedside” approach, using basic and translational research to address clinically relevant problems. Through close collaboration between basic scientists, clinicians, and biologists at the Nîmes University Hospital, we use integrative and multidisciplinary approaches to understand the cellular and molecular basis of host-pathogen interactions and microbial interactions in chronic wounds, and to apply our findings to clinical practice. We are also the National Reference Center for Brucellosis. We focus on the following conditions: Brucellosis; Opportunistic infections caused by the Burkholderia cepacia complex; Chronic wound infections; Staphylococcal infections. Label: Joint Research Unit Research UMR) Main sponsoring organizations:UM, Inserm Research cluster: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: the unit’s publications WEBSITE

https://youtu.be/b6lRTV9H6AA?list=PL6WmOx60MnJe_iazdaxlxc1zC3Mx1K3Z0 Le laboratoire de Physiologie et Médecine Expérimentale du Cœur et des muscles, PhyMedExp, est une unité mixte de recherche (INSERM, CNRS, Université de Montpellier) créée le 1er janvier 2011. C’est une unité pluridisciplinaire fédérée autour de la physiologie et la physiopathologie des tissus contractiles (muscles cardiaque, lisse et strié), et leurs interactions avec leur environnement. Elle regroupe plus de 150 personnes sur 5 équipes et développe une stratégie de recherche allant de structures élémentaires (gènes et molécules), à l’organisme entier en passant par les cellules et les tissus. Les 5 équipes de la nouvelle unité PHYMEDEX sont : Équipe N°1 : Dynamique des couplages cardiaques. Équipe N°2 : Muscle et Déficiences d’Organes. Équipe N°3 : Maladies respiratoires et environnement. Équipe N°4 : Digestif : Développement et pathologies. Équipe N°5 : Maladies neuromusculaires et héréditaires. Label : Unité Mixte de Recherche (UMR)Tutelles principales : UM, Inserm, CNRSPôle de recherche : Biologie SantéÉcoles doctorales : Sciences du mouvement humain ; Sciences Chimiques et Biologiques pour la SantéPortail HAL : publications de la structure Site web

A multidisciplinary research unit composed of INSERM scientists, university researchers, and university hospital researchers. With expertise in the field of infectious disease research, UMR 1058 promotes translational research—bridging basic and clinical research—on the pathogenesis, transmission, and control of HIV, other chronic infections (hepatitis viruses, mycobacteria), and emerging infections (arboviruses, prions), most often in partnership with research teams from the Caribbean and countries in the Global South (sub-Saharan Africa and Southeast Asia). UMR 1058 is supported by and has received research funding from ANRS, ANR, the European Union (EDCTP and FP7), NIH/NIDA, and various foundations. Label: Joint Research Unit Research UMR)Primary sponsoring institutions:UM, Inserm, U ANTILLESResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: the unit’s publications WEBSITE

The MMDN is an interdisciplinary laboratory dedicated to research on the biology of aging and neurodegenerative diseases. We seek to understand the molecular mechanisms underlying normal and pathological aging and to propose new approaches for diagnosis and treatment.Using animal models such as fruit flies, zebrafish, mice, and lemurs, and employing methods from molecular biology, cell biology, and pharmacology, we focus on neurodegenerative diseases (Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis), rare diseases, and spinal cord injury. Label: Joint Research Unit Research UMR)Main sponsoring organizations:UM, Inserm, EPHEResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: the unit’s publications WEBSITE

The research conducted by the LPHI teams aims to advance our understanding of biological membranes, particularly in the context of parasitic (malaria, toxoplasmosis), bacterial (tuberculosis, salmonellosis, staphylococcal infections), and viral (antiviral defenses) infectious processes. The LPHI unit prioritizes high-quality, innovative basic research in the field of biology. The research relies on integrated approaches that draw on genetics, molecular biology, biochemistry, structural biology, and cellular biology—both in vitro and in vivo. The laboratory collaborates with chemists and hosts a team of theorists, physicists, and mathematicians to combine biology, chemistry, physics, and mathematics in comprehensive or targeted multidisciplinary approaches to the biological processes under study. Designation: Joint Research Unit Research UMR)Primary sponsoring organizations: CNRS, INSERM, UMPResearch cluster: Biology and HealthDoctoral schools: Information, Structures, Systems; Chemical and Biological Sciences for HealthHAL portal: publications from the unit WEBSITE

The goal of the research conducted by the Bioengineering and Nanoscience Laboratory is to contribute to the application of nanoscience in the fields of health and biology, with a particular focus on dentistry. The primary goal is to advance the clinical application of nanomaterials and nanosensors using a high-quality methodological approach. Label: UR_UM104Primary supervising institution: UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: publications from the unit WEBSITE

The IRMB brings together scientists and clinicians involved in regenerative medicine and immunotherapies, covering both aspects of basic biology and innovative applications of regenerative therapy. The goal is to facilitate the transfer of research on stem cell biology to clinical applications in coordination with clinicians specializing in chronic diseases (aging, rheumatoid arthritis, rare genetic diseases, diabetes, liver diseases, neurodegenerative diseases, and musculoskeletal disorders). Designation: Joint Research Unit Research UMR)Primary sponsoring organizations:UM, InsermResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: the unit’s publications WEBSITE

Infectious diseases account for 35% of deaths worldwide and are the leading cause of death among children and young adults. Furthermore, it is estimated that 17% of new cancer cases are caused by infectious agents. Research in infectious diseases is therefore essential to better understand how an infectious agent multiplies within a living organism, in order to prevent, treat, or even cure the diseases caused by these infections. The IRIM (Montpellier Institute for Research Infectious Diseases) is a research center focused primarily on high-quality basic research in the fields of bacteriology, virology, and immunity. Designation: Joint Research Unit Research UMR)Primary sponsoring agencies: CNRS, UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: the unit’s publications WEBSITE

The IRCM conducts cognitive, multidisciplinary, and applied research in the field of oncology. This research involves researchers and clinicians and aims to understand the various stages of tumorigenesis and, ultimately, to identify new diagnostic and therapeutic strategies for cancer. The Institute’s overarching theme is “Molecular Targets and Cancer Therapy: Discovery, Biology, and Clinical Applications.” The teams’ projects are organized around two main areas of focus: Therapeutic Antibodies in Oncology: innovation, engineering, and biological response; Plasticity of solid tumors and their microenvironment: phenotypic and signaling pathway plasticity, genetic and epigenetic alterations, and treatment resistance. Label: Joint Research Unit Research UMR) Main sponsoring organizations:UM, Inserm, ICM Research cluster: Biology and Health Doctoral schools: Information, Structures, Systems; Chemical and Biological Sciences for Health HAL portal: the unit’s publications WEBSITE

The Montpellier Institute of Neuroscience aims to study the pathophysiology and treatments of sensory (hearing, vision, somatosensory) and motor deficits. In their research, the teams rely on multidisciplinary approaches—ranging from molecular genetics, cellular imaging, and electrophysiology to the study of integrated systems—to develop preclinical trials. The INM teams address various research topics: Genetics and therapy of retinal blindness; Physiology and pathophysiology of the inner ear; Development and pathophysiology of proprioceptive systems; Physiology and therapeutic approaches to spinal cord disorders. Designation: Joint Research Unit Research UMR) Main sponsoring organizations:UM, Inserm Research cluster: Biology and Health Doctoral school: Chemical and Biological Sciences for Health HAL portal: the unit’s publications WEBSITE

Label: UR_UM103 Primary Affiliations:UM, Nîmes University Hospital Research Cluster: Biology and Health Doctoral Schools: Chemical and Biological Sciences for Health; Information, Structures, Systems HAL Portal: publications from this unit

The IGMM conducts innovative, world-class basic research with potential applications in the fields of biomedicine and molecular and cellular medicine, particularly for the treatment of cancer and certain infectious or genetic diseases. The IGMM has a long-standing, internationally recognized reputation in the disciplinary fields that constitute its main research areas: RNA Biology; Gene Regulation and Epigenetics; Tumorigenesis/Cell Cycle and Cell Death; Immunology/Virology/Biotherapies. In addition to these main areas, the IGMM is also driven by a cross-disciplinary approach involving mathematical/computational modeling and machine learning to better understand the pathophysiological phenomena at the heart of its scientific interests.Translational research plays an increasingly important role in the IGMM’s research, with a growing number of hospital partnerships in and outside Montpellier and the inclusion of hospital practitioners in its teams. Label: Joint Research Unit Research UMR)Primary sponsoring agencies: CNRS, UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: the unit’s publications WEBSITE

The IGH conducts cutting-edge basic research and aims to advance it to the point of yielding applications in the field of pathology. The main research themes focus on genome and chromatin dynamics, developmental genetics, epigenetic regulation, and molecular and cellular pathologies. Three major research areas have been established within the IGH: Genome dynamics and epigenetic regulation. The main aspects of this research include DNA replication, maintenance of genomic integrity, recombination and meiosis, retrotransposition and its regulation, chromatin and nuclear organization, regulation of gene expression, and RNA silencing. Developmental genetics. This research relies heavily on model organisms such as Drosophila and transgenic mice. Topics addressed include the cell cycle and microtubule dynamics, gonadal development, RNA regulation in development, neurogenetics, and memory. Understanding, diagnosis, and treatment of human diseases. This research focuses on DNA metabolism, epigenetic regulation and signaling pathways in cancer, the molecular basis of myogenesis, immunity, inflammatory diseases, AIDS, neurodegenerative diseases, and cell therapies. Designation: Joint Research Unit Research UMR)Primary sponsoring agencies: CNRS, UMPResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: the unit’s publications WEBSITE

The Institute of Functional Genomics (IGF) is a multidisciplinary research center. The IGF’s primary focus is on basic research that uses functional genomics to explore normal and pathological cellular signaling and communication processes in various fields, particularly neurobiology, cardiology, endocrinology, and oncology. Its main activities range from structural pharmacology to systems biology, and from the development of preclinical disease models to translational research, all aimed at studying various pathologies, including neurological and psychiatric disorders, cardiac dysfunction, diabetes, and cancer. One of the IGF’s main objectives is to identify new concepts in molecular medicine and to evaluate new strategies for the development of diagnostic and therapeutic tools. Label: Joint Research Unit Research UMR)Main sponsoring organizations: CNRS, UM, InsermResearch cluster: Biology and HealthDoctoral school: Chemical and Biological Sciences for HealthHAL portal: the unit’s publications WEBSITE

The Desbrest Institute of Epidemiology and Public Health (IDESP) aims to understand the development and progression of chronic diseases, which affect more than 30% of the population and account for 80% of healthcare spending. To achieve this, Research University of Montpellier Joint Research Unit employs a new approach that takes into account the environment in the broadest sense and care trajectories through multimodal markers (clinical, biological, behavioral, psychological, social, and environmental), drawing on the power of mathematics applied to big data. Its goal is to design optimized care and prevention pathways for relevant patient populations. Allergic and respiratory diseases, diabetes, obesity, kidney and vascular diseases, inflammatory rheumatic diseases, and cancers are the focus of the initial modeling efforts. Label: Joint Research Unit Research UMR)Primary sponsoring organizations:UM, InsermResearch cluster: Biology and HealthDoctoral schools: Information, Structures, Systems; Chemical and Biological Sciences for HealthHAL portal: the unit’s publications WEBSITE - HAL page

GENOPOLYS facilitates the organization of meetings, conferences, and workshops through its meeting rooms, lecture hall, and two laboratory spaces, all focused on biology and health. GENOPOLYS serves as a hub for exchange, catering to: the general public, with the goal of contributing to citizens’ scientific and medical literacy and fostering dialogue between science and society;researchers and physicians, by promoting the integration of clinical research with basic research;industry professionals, with the goal of integrating the research community into the corporate world through training, interaction, and development. Designation: Research Support Unit Research UAR)Primary sponsoring organizations: CNRS, UM, InsermResearch cluster: Biology and Health WEBSITE